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Background Box C/D snoRNPs are responsible for rRNA methylation and processing, and are formed by snoRNAs and four conserved proteins, Nop1, Nop56, Nop58 and Snu13. The snoRNP assembly is a stepwise process, involving other protein complexes, among which the R 2 TP and Hsp90 chaperone. Nop17, also known as Pih1, has been shown to be a constituent of the R 2 TP (Rvb1,...
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