Central European Journal of Medicine

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Welcome Message from the Editor-in-Chief

J. John Mann

Central European Journal of Medicine > 2006 > 1 > 1 > 1-1

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Radiofrequency pulmonary veins isolation of atrial fibrillation in patients undergoing mitral valve replacement

Maciej L. Grabowski, Tomasz Hryniewiecki, Tomasz Gawałkiewicz, Janina Stępińska, more

Central European Journal of Medicine > 2006 > 1 > 1 > 58-68

Introduction: Pulmonary veins isolation (PVI) is useful method in patients (pts) with mitral valve disease (MVD) and chronic atrial fibrillation (AF) during prosthetic valve implantation. The aim of the study: To evaluate e.ectiveness of PVI in the treatment of AF in pt with MVD during valve implantation. Material and methods: 45 pts (mean age 55 yrs) with AF were operated on for MVD.RF ablation around...

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Multiple primary malignant neoplasms — case report

Cornelia Amalinei, Raluca Balan, Luminita Ivan, Razvan Socolov, more

Central European Journal of Medicine > 2006 > 1 > 1 > 87-98

The synchronous occurence of primary carcinomas of endometrium and ovary is well recognized. Malignant peripheral nerve sheath tumours (MPNSTs) may also rarely occur in patients diagnosed with malignancies of the female genital tract. We report a rare case of synchronous primary carcinomas of endometrium and ovary, followed by a metachronous retroperitoneal MPNST. Ascites cytology and endometrial...

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Cytostatic therapy and blood antioxidants/prooxidants balance in acute myeloblastic leukemia patients

Daniela I. Gerova, Vladimir T. Gerov, Tatyana M. Yankova, Liana T. Gercheva, more

Central European Journal of Medicine > 2006 > 1 > 1 > 35-45

To analyze the effects of conventional polychemotherapy of acute myeloblastic leukemia (AML) patients on the prooxidants/antioxidants balance in plasma total antioxidant status (TAS) and a single plasma antioxidant — uric acid (UA) were measured. Lipid peroxidation was assessed by malonedialdehyde (MDA) content. Total serum iron was monitored as a potential source of nontransferrin-bound iron with...

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Whole bowel irrigation (WBI) in acute iron poisoning — case report

Dorota Klimaszyk, Magdalena Łukasik-Głębocka

Central European Journal of Medicine > 2006 > 1 > 1 > 81-86

Objective: In theory, WBI (whole bowel irrigation) is indicated in iron poisoning, but the existing data are still insufficient to support or exclude its efficacy. Case report: A 46 year-old female admitted to the Toxicology Department due to suicidal ingestion of 5000 miligrams of elemental iron (57 mg/kg) in sustained-release preparation. WBI was instituted at 2 hours after ingestion, because...

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Estimate of antioxidant capacity and lipid peroxidation in plasma of healthy subjects

Anna Gorąca, Beata Skibska

Central European Journal of Medicine > 2006 > 1 > 1 > 23-34

Serum contains various antioxidant molecules that may provide important protection against free radical attack. The aim of this work was to assess the total antioxidant capacity of plasma and a marker of lipid per oxidation [(thiobarbituric acid-reactive substances (TBARS)] in plasma of healthy smoking and non-smoking young and elderly subjects. In addition, we investigated plasma concentrations of...

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Unusual case of double acute intoxication with tamoxifen complicated by miscarriage

Jacek Sein Anand, Zygmunt Chodorowski, Roman P. Korolkiewicz, Dorota Klimaszyk, more

Central European Journal of Medicine > 2006 > 1 > 1 > 99-102

Background: A 24-year-old female had attempted suicide twice, at the age of 20 and 24, using tamoxifen. Case report: Subsequent to the first acute intoxication a development of bilateral ovarian cysts was observed. Cysts regressed spontaneously within 8 weeks. Five weeks after the second suicidal attempt, pregnant patient (15 weeks of gestation) was admitted to the hospital with vaginal bleeding and...

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Spatial visualisation and quantification of expression of cell specific markers — an application for chronic parathyroiditis cases

Elżbieta Kaczmarek, Rafał Strzelczyk, Agnieszka Górna, Przemysław Majewski

Central European Journal of Medicine > 2006 > 1 > 1 > 46-57

The aim of this work was to develop a simple and fast technique for spatial visualisation of colour cell specific markers in digital microscopy. Colour light microscopy images were transformed into their spatial representation by introducing image brightness as the third dimension. Based on spatial representation, the expression of selected colour specific markers was assessed by their surface, volume,...

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Evaluation of TV cell line viral susceptibility using conventional cell culture techniques

Coralia Bleotu, Carmen C. Diaconu, Mihaela Chivu, Irina Alexiu, more

Central European Journal of Medicine > 2006 > 1 > 1 > 12-22

Despite the fact that a lot of methods have been developed for rapid virus detection, classic cell culture is still “the golden standard”. The range of viruses that can be isolated and cultured in cell line systems is often limited by the susceptibility of cells to support viral replication. Since the primary cell culture, the best cellular system available to support replication of a large number...

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Communicating risks of foodborne diseases

Tanja M. Wildemann

Central European Journal of Medicine > 2006 > 1 > 1 > 69-80

Foodborne diseases contribute substantially to the overall burden of disease, including hospitalizations, economic loss, and death. Nonetheless, in contrast to food safety experts, the public usually perceives foodborne diseases as low risk, which highlights the differences in the perception of the risk. Many studies have shown that risk perception is a complex concept determined by a variety factors...

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Changes of the expression of insulin-like growth factor 1 and its two receptors in the periphery of the developing lung are parallel to ultrastructural capillary changes during perinatal period

Andrzej Marszałek, Wiesława Biczysko, Tsutomu Daa, Elżbieta Kaczmarek, more

Central European Journal of Medicine > 2006 > 1 > 1 > 2-11

Insulin-like growth factor type 1 (IGF-1) belongs to the peptide hormones which regulate cell proliferation and differentiation as well as angiogenesis. The aim of the present study was the quantitative evaluation of immuohistochemical (IH) expression of IGF-1 and its two receptors (IGF-1Rα and IGF-1Rβ) parallel to changes of capillary lumen/whole capillary area (L/W) ratio during the perinatal period...

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Student scientific activity at the Bratislava medical faculty 2000–2004. A scientometric study

Peter Celec, Július Hodosy

Central European Journal of Medicine > 2006 > 1 > 2 > 172-178

Students at the Bratislava medical faculty interested in research can participate voluntarily in a student scientific activity (SSA). Currently, the scientific activity is measured by the quantity and quality of publications and these scientometric parameters are important for grant evaluations as well as for individual careers. In this study, we evaluate the publication successes of SSA papers presented...

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Selected elements of psychical health among 40-year-old persons

Tomasz Maksymiuk

Central European Journal of Medicine > 2006 > 1 > 2 > 158-161

The psychical health of 40-year-old inhabitants of the City and the (former) Province of Poznan, Poland were examined as part of a larger research project on their general state of health. The study focused on the incidence of past psychical disorders among the subjects themselves, their parents, their siblings, and their children. The perceptions of the study group with respect to their own emotional...

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A clinical comparison of the Laryngeal Tube™ and the Laryngeal Mask™ in spontaneously breathing anesthetized patients

Johanna Albert, Leif Kindlund, Barbro Nilvér, Waldemar Gożdzik

Central European Journal of Medicine > 2006 > 1 > 2 > 162-171

Background: The laryngeal mask airway (LMA) can be used in general anaesthesia without neuromuscular block. The laryngeal tube (LT) is a new airway device with similar airway features as LMA. LT is provided with a distal cuff to prevent regurgitation. In this study we compared the LMA and LT concerning patient and user aspects. Methods: Sixty patients with ASA (American Society of Anestesiologists)...

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Abnormal ECG patterns during the acute phase of subarachnoid hemorrhage in patients without previous heart disease

Penka A. Atanassova, Maria P. Tokmakova, Albena A. Djurkova, Vulcho Naydenov, more

Central European Journal of Medicine > 2006 > 1 > 2 > 148-157

Subarachnoid hemorrhage (SAH) occurs primarily during early to mid-adulthood; approximately 30% of individuals with SAH die within 2 weeks, and mortality is 30% to 45%. SAH happens suddenly, without patients being aware of previous heart abnormalities. Here, we performed a pilot single cohort (historical) study to examine the hypothesis that early abnormal electrocardiographic (ECG) changes may reveal...

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Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin

Victoria S. Sarafian, Dorian I. Dikov, Milen P. Karaivanov

Central European Journal of Medicine > 2006 > 1 > 2 > 119-127

Although the precise biological role of lysosomal membrane-associated glycoproteins (LAMPs) and ABH histo-blood group antigens (HBGAs) remains somewhat unclear, they are thought to be related to cell differentiation, cellular adhesion, and tumorigenesis. Here, we present the first comparative immunohistochemical study of both LAMPs and HBGAs in normal and neoplastic skin. Their localization is compared...

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The relationship between features of metabolic syndrome and blood adipocytokine concentrations in the morbid obese patients during dynamic weight loss

Joanna Jankiewicz-Wika, Krzysztof Kołomecki, Jacek Cywiński, Katarzyna Piestrzeniewicz, more

Central European Journal of Medicine > 2006 > 1 > 2 > 136-147

Bariatric surgery is the most effective method to achieve weight loss in obese subjects. The aim of this study was to evaluate some adipocytokines and insulin, as well as parameters of metabolic syndrome of the obese patients, for three and six months after vertical banded gastroplasty, in the time of dynamic weight loss. Seven males and two females aged 28 to 49 years, with long lasting simple obesity...

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Molecular screening for hereditary nonpolyposis colorectal cancer in Bulgaria

Tanya K. Kadiyska, Teodora E. Goranova, Ganka K. Dineva, Dimitar G. Nedin, more

Central European Journal of Medicine > 2006 > 1 > 2 > 128-135

Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease, caused by germline mutations in DNA mismatch-repair genes (MMR). These mutations lead to microsatellite instability (MSI). It has been found that the MSI is not confined to the setting of hereditary disease and may be seen in approximately 12-17% of the sporadic CRCs. In 1998 a National Registry for CRC was instituted...

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Is radiocontrast-induced nephropathy avoidable? The scientific evidence in 2006

Paul Gusbeth-Tatomir, Serban Ardeleanu, Adrian Covic

Central European Journal of Medicine > 2006 > 1 > 2 > 103-118

Due to the wide use of radiocontrast agents (RCA) in modern radiology and interventional cardiology, the incidence of radiocontrast-induced nephropathy (RCIN) is increasing. The risk factors for RCIN are primarily pre-existing (even mild) renal dysfunction, diabetes mellitus, absolute or relative hypovolemia, nephrotoxic drugs, etc., particularly in elderly patients. The presence of these risk factors...

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Fatal outcome of pyoderma gangrenosum with multiple organ involvement and partially responding to Infliximab

Stefan Drinda, Peter Oelzner, Carolina Codina Canet, Martin Kaatz, more

Central European Journal of Medicine > 2006 > 1 > 3 > 306-312

Pyoderma gangrenosum is an inflammatory dermatosis of uncertain etiology, often associated with chronic inflammatory bowel or rheumatoid disease. It predominantly affects the skin. A systemic organ involvement caused by aseptic neutrophilic abscesses, however, fundamentally influences the prognosis. A patient with idiopathic pyoderma gangrenosum insufficiently responded to a conventional immune suppressive...

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Central European Journal of Medicine

Welcome Message from the Editor-in-Chief

Radiofrequency pulmonary veins isolation of atrial fibrillation in patients undergoing mitral valve replacement

Multiple primary malignant neoplasms — case report

Cytostatic therapy and blood antioxidants/prooxidants balance in acute myeloblastic leukemia patients

Whole bowel irrigation (WBI) in acute iron poisoning — case report

Estimate of antioxidant capacity and lipid peroxidation in plasma of healthy subjects

Unusual case of double acute intoxication with tamoxifen complicated by miscarriage

Spatial visualisation and quantification of expression of cell specific markers — an application for chronic parathyroiditis cases

Evaluation of TV cell line viral susceptibility using conventional cell culture techniques

Communicating risks of foodborne diseases

Changes of the expression of insulin-like growth factor 1 and its two receptors in the periphery of the developing lung are parallel to ultrastructural capillary changes during perinatal period

Student scientific activity at the Bratislava medical faculty 2000–2004. A scientometric study

Selected elements of psychical health among 40-year-old persons

A clinical comparison of the Laryngeal Tube™ and the Laryngeal Mask™ in spontaneously breathing anesthetized patients

Abnormal ECG patterns during the acute phase of subarachnoid hemorrhage in patients without previous heart disease

Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin

The relationship between features of metabolic syndrome and blood adipocytokine concentrations in the morbid obese patients during dynamic weight loss

Molecular screening for hereditary nonpolyposis colorectal cancer in Bulgaria

Is radiocontrast-induced nephropathy avoidable? The scientific evidence in 2006

Fatal outcome of pyoderma gangrenosum with multiple organ involvement and partially responding to Infliximab

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