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Purpose. The aim was to assess the feasibility of cutaneousmicrodialysis as a method to study percutaneous penetration of methyl nicotinatethrough human skin in vitro and in vivo. Methods. Microdialysis was applied in vitro in excised human skin,in isolated dermis, in reconstructed human epidermis and in vivo inthe volar forearm skin of volunteers using methyl nicotinate (MN) asa model compound...
Purpose. To quantify the contribution of distributional processes across the blood-brain barrier (BBB) to the delay in antinociceptive effect of morphine in rats. Methods. Unbound morphine concentrations were monitored in venous blood and in brain extracellular fluid (ECF) using microdialysis (MD) and in arterial blood by regular sampling. Retrodialysis by drug was used for in vivo calibration...
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