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Purpose. The aim of this study was to evaluate the ability of anin vitro method of tissue distribution to accurately predict total water andextracellular aqueous spaces using marker compounds urea and inulin. Methods. Slices (50–200 mg) of all the major tissues in the rat wereincubated with Hanks/HEPES pH7.4 buffer containing 14C-urea and3H-inulin for 2 h at 37°C. Tissue weight was noted before...
Purpose. Amphotericin B in small, unilamellar liposomes (AmBisome) is safer and produces higher plasma concentrations than other formulations. Because liposomes may increase and prolong tissue exposures, the potential for drug accumulation or delayed toxicity after chronic AmBisome was investigated. Methods. Rats (174/sex) received intravenous AmBisome (1, 4, or 12 mg/kg), dextrose, or empty...
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