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Purpose. Implantation of biodegradable polymers provides a powerfulmethod to deliver high, sustained concentrations of chemotherapeuticsto brain tumors. The present studies examined the ability of injectablepolymeric microspheres, formulated to release carboplatin or BCNUfor 2–3 weeks, to enhance survival in a rodent model ofsurgically-resected glioma. Methods. Rat glioma (RG2) cells were implanted...
Purpose. Delivery of chemotherapeutics using implantable,biodegradable polymers provides a potentially powerful method of treating braintumors. The present studies examined the ability of injectablemicrospheres, formulated to release carboplatin or BCNU for 2–3 weeks,to enhance survival in a rodent model of deep, inoperable glioma. Methods. Rat glioma (RG2) cells were implanted into the striatum...
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