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Purpose. We are exploring liposomal delivery with the aim to changethe pharmacokinetics and biodistribution of SOD to increase itstherapeutic activity. From a practical point of view, a convenient route ofadministration would be the subcutaneous (s.c.) route. Liposomal sizehas been shown to be the most important factor influencing the rateand extent of drainage of liposomes from the s.c. injection...
Purpose. This study compared the biodistribution of two amphotericin B formulations in normal and Aspergillus infected mice. Amphotericin B cholesterol hemisuccinate vesicles (ABCV) which reduces the toxicity of amphotericin B and thereby enhances its therapeutic efficacy in a murine model of aspergillosis was compared with conventional amphotericin B deoxycholate suspension (AmBDOC). Methods...
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