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Objective To enhance the differentiation of mesenchymal stem cells (MSCs) and their epigenetic status by modification using hypomethylating agents (HMAs) and histone deacetylase inhibitors (HDACs). Results Treatment with 5-azacytidine or 5-azacytidine plus trichostatin A (TSA) increased expression of Runx-2, BDNF and Sox-9 compared with the control or TSA groups. Maximal increases of 4.1-, 4.5-,...
Objective To investigate the role of cytosine methylation in regulation of polyketide compounds biosynthesis in larvae of Strongylocentrotus intermedius. Results Treatment of S. intermedius larvae with 100 and 200 µM 5-azacytidine (5A) as a DNA demethylating agent significantly increased the amounts of spinochrome D and spinochrome E, as the number of pigmented cells per studied larva, in a dose-depended...
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