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Background In esophageal squamous cell carcinoma (ESCC), it has been reported that some genes are associated with lymph node (LN) metastasis. The intent of this study was to clarify the relation between LN micrometastasis and gene expression in ESCC. Methods Micrometastasis of 2749 LN of 67 patients with thoracic ESCC were examined by cytokeratin staining. Of 67 patients, 38 were pN0 and 29 were...
Background In esophageal carcinoma, the clinical significance of immunohistochemically (IHC)-detected lymph node (LN) micrometastasis is still controversial. We designed this multicenter study to determine the clinical significance of IHC-detected LN micrometastasis in esophageal carcinoma. Methods The subjects were 164 patients with histopathologically confirmed LN-negative esophageal carcinoma...
Background Whether the prognostic abilities of markers of lymphatic spread are affected by preoperative chemotherapy or chemoradiotherapy for esophageal cancer has not been clarified. The purpose of this study was to determine significant prognostic predictors related to lymphatic spread in potentially curable esophageal cancer according to preoperative treatment status. Methods The prognostic significance...
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