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Symptoms, endoscopy, and pathology are key factors in diagnosing gastroesophageal reflux disease (GERD). Endoscopy has seen relevant improvements (magnifying endoscopy, chromoendoscopy, narrow band imaging, autofluorescence, endomicroscopy) during the past years, allowing more-targeted biopsies. However, histological diagnosis of gastroesophageal reflux disease (GERD) remains difficult. Previous publications...
Background Assessment of the outcomes of laparoscopic fundoplication in elderly patients with gastroesophageal reflux disease (GERD) is insufficient. Methods Of the 256 patients with GERD who underwent surgery between December 1994 and December 2008, sufficient postoperative follow-up was completed in 205 patients. Of the 205 patients who were included in the study, 166 were younger than 70 years...
Purpose The number of operations for laparoscopic antireflux surgery in Japan is much less than that in Western countries. This study’s aim was to evaluate outcome measures for redo antireflux surgery (redo-ARS) in Japanese patients. Methods Subjects consisted of 11 patients (2.3 %) who required redo-ARS, from an original group of 474 patients who had a primary ARS between December 1994 and January...
Background Gastroesophageal reflux disease (GERD) is one of the most frequent disorders in daily clinical practice with numerous associated consequences. A large number of studies were conducted to determine the prevalence of GERD and its associated risk factors which led to inconsistent results. The present study was performed to evaluate the prevalence of GERD and its related risk factors in north...
The cause of reflux esophagitis (RE) is excessive esophageal acid exposure. Acid reflux and acid clearance after acid reflux are important factors related to excessive esophageal acid exposure. The main mechanism responsible for acid reflux is transient lower esophageal sphincter relaxation (TLESR), which is LES relaxation not associated with swallowing, and acid reflux caused by low LES pressure...
Background Surgical results of GERD have mainly been reported from the Western countries, with a few reports found in Japan. We examined the surgical results of laparoscopic Toupet fundoplication and clarify the characteristics of recurrent cases. Methods The subjects included 375 patients who underwent laparoscopic Toupet fundoplication from June 1997 to December 2016 as the initial surgery. Patient...
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