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Nadifloxacin, a second generation fluoroquinolone, is a topical antibiotic prescribed for acne vulgaris. For any drug, understanding the stability profile is of vital significance as it correlates with the safety and potency of the drug. In the present study, the degradation behaviour of nadifloxacin was studied under different forced degradation conditions. The drug was subjected to acidic, basic,...
Enzalutamide was recently approved for the treatment of castration-resistant prostate cancer. In this study, the related substances in enzalutamide bulk substance were analyzed qualitatively and quantitatively. Four degradation products (Oxi, A9, P1 and P2) of enzalutamide were isolated using semi-preparative liquid chromatography and characterized using nuclear magnetic resonance and mass spectrometry...
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