Archivum Immunologiae et Therapiae Experimentalis

Items from 1 to 20 out of 697 results

article

The effect of Chlamydia trachomatis infection of the prostate gland on the concentration of citric acid

Bożena Zdrodowska-Stefanow, Iwona Ostaszewska-Puchalska, Jerzy Badyda, Zofia Galewska

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 1 > 69-73

. Introduction The objective of the study was to assess the relationship between Chlamydia trachomatis (C.t.) infection of the prostate and the concentration of citric acid. Materials and Methods: The study involved 60 patients with chronic prostatitis (NIH III). Urethral swabs and expressed prostatic secretions (EPS) were collected for analysis. The urethral swabs were tested for PMNs and the presence...

article

Activation of Salmonella-specific immune responses in the intestinal mucosa

Aparna Srinivasan, Stephen J. McSorley

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 1 > 25-31

Summary. The mammalian immune response to Salmonella has long been a subject of scientific study. Indeed, many of the general aspects of bacterial pathogenesis and host immune defense have been well described. However, a lack of clarity remains concerning important aspects of the host immune response to Salmonella, particularly with regard to the induction of an immune response in the intestinal mucosa...

article

Treating autoimmune diseases through restoration of antigen-specific immune tolerance

Lawrence A. Wolfraim

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 1 > 1-13

. The first line of treatment for many human autoimmune diseases involves the use of anti-inflammatory or immunosuppressive drugs such as prednisone or other steroids that not only suppress the underlying autoimmune disease, but lead to global suppression of the immune system. The sequelae of this approach include increased risk of infection, carcinogenesis, and osteoporosis. Moreover, such broad...

article

Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27

Carol Beadling, Mark K. Slifka

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 1 > 15-24

. The functional characterization and subsequent purification of T cell growth factor/interleukin (IL)-2 in the early 1980s established this secreted protein as a key mediator of immune cell activation and provided the prototype that enabled the discovery of numerous cytokines over the ensuing two decades. While soluble immunoregulatory factors were initially identified functionally as biological...

article

Routine clinical laboratory tests correspond to increased serum levels of 3-hydroxy fatty acids, markers of endotoxins, in cardiosurgery patients

Leonard Kraśnik, Bogumiła Szponar, Maciej Walczak, Lennart Larsson, more

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 1 > 55-60

. Introduction: Endotoxemia developing during cardiosurgery as elevated endotoxin concentrations in patient’s serum may prevail over 24 h after operation. A major reason is thought to be increased gut permeability resulting in endotoxin and bacterial leakage. In this study we aimed to measure endotoxin levels on samples obtained during and after cardiovascular procedures and compare them with clinical...

article

Regulatory T cells: magic bullets for immunotherapy?

Oliver Frey, Rolf Bräuer

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 1 > 33-43

. In the past few years it has been become increasingly clear that T cells capable of actively suppressing immune responses are thought to be in part responsible for the maintenance of peripheral self tolerance. In healthy rodents and humans, CD4⁺ T cells constitutively expressing the interleukin (IL)-2 receptor α-chain (CD25) are able to exert such suppressive function in vitro and in vivo. Despite...

article

Stem cells in nephrology: present status and future

Ewa Wątorek, Marian Klinger

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 1 > 45-50

. Stem cell biology is currently developing rapidly because of the potential therapeutic utility of stem cells. The ability to acquire any desired phenotype raises hope for regenerative therapies. Manipulation of these cells is a potentially valuable tool; however, the mechanisms of stem cell differentiation and plasticity are currently beyond our control. In the field of nephrology, the presence...

article

Therapeutic effects of cisplatin on rat experimental autoimmune encephalomyelitis

Xiao-Bo Li, Hermann J. Schluesener

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 1 > 51-53

. Introduction: Experimental autoimmune encephalomyelitis (EAE) is a prototypic Th1-mediated autoimmune inflammatory disease of the central nervous system (CNS), and serves as a model for the human demyelinating disease, multiple sclerosis. Cisplatin is a drug widely used in the treatment of a variety of human neoplasias, such as advanced bladder carcinoma, adrenal cortex carcinoma, breast cancer,...

article

Susceptibility of Propionibacterium acnes and Staphylococcus epidermidis to killing by MPO-halide system products. Implication for taurine bromamine as a new candidate for topical therapy in treating acne vulgaris

Janusz Marcinkiewicz, Rafał Biedroń, Anna Białecka, Andrzej Kasprowicz, more

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 1 > 61-68

. Introduction: Taurine chloramine (TauCl) and taurine bromamine (TauBr) are the main haloamines produced by activated neutrophils. TauCl exerts both anti-inflammatory and microbicidal activities. Clinical studies showed that TauCl may be useful as an antimicrobial agent in the local treatment of infections. Much less is known about TauBr. Circumstantial evidence suggests that Propionibacterium acnes...

article

Elevated TGF-β1 concentration in bronchoalveolar lavage fluid from patients with primary lung cancer

Joanna Domagała-Kulawik, Grażyna Hoser, Aleksandra Safianowska, Hanna Grubek-Jaworska, more

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 2 > 143-147

. Introduction: Transforming growth factor (TGF)-β is one of numerous inhibitory factors produced by cancer cells that regulate antitumor immunity. The aim of this study was to evaluate TGF-β1 levels and lymphocyte subsets in the broncholaveolar lavage fluid (BALF) of patients with primary lung cancer and to analyze the interdependence of these parameters. Materials and Methods: BALF samples were...

article

Monoclonal and bispecific antibodies as novel therapeutics

Evan P. Booy, Dina Johar, Srilekha Maddika, Hasan Pirzada, more

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 2 > 85-101

. Gene amplification, over-expression, and mutation of growth factors, or the receptors themselves, causes increased signaling through receptor kinases, which has been implicated in many human cancers and is associated with poor prognosis. Tumor growth has been shown to be decreased by interrupting this process of extensive growth factor-mediated signaling by directly targeting either the surface...

article

The distinctive role of small heat shock proteins in oncogenesis

Krzysztof Laudanski, Dorota Wyczechowska

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 2 > 103-111

. Recently, the role of small heat shock proteins (HSPs) has been widely recognized in cancer research. Small HSPs are tumorprotective via numerous, independent mechanisms such as: oxidative stress, protection preventing protein denaturation, anti-apoptotic activity, and likely direct suppression of the immune system. However, it is unclear whether they play any role in the initial steps in carcinogenesis...

article

The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner

Magda Kucia, Wojtek Wojakowski, Ryan Reca, Bogdan Machalinski, more

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 2 > 121-135

. Introduction: Recently we identified in bone marrow (BM) by employing chemotactic isolation to SDF-1 gradient combined with real time RT-PCR analysis a mobile population of CXCR4⁺ BM mononuclear cells that express mRNA for various markers of early tissue-committed stem cells (TCSCs). In this study we evaluated whether TCSCs respond to other motomorphogens, such as hepatocyte growth factor (HGF)...

article

Novel therapies of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter spp . infections: the state of the art

Marta Wróblewska

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 2 > 113-120

. Gram-negative non-fermenting bacilli, particularly Pseudomonas aeruginosa and Acinetobacter spp., are important opportunistic pathogens in hosppitalized patients, contributing to their morbidity and mortality. Recently, a rapid increase in frequency of multidrug-resistant clinical strains is being recorded, making the available therapeutic options very limited. Apart from the development of novel...

article

Toll-like receptors types 2 and 6 and the apoptotic process in human neutrophils

Ewa Jabłońska, Magdalena Marcińczyk, Jakub Jabłoński

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 2 > 137-142

. Introduction: Neutrophils (PMN) apoptosis plays an important role in limiting the last phase of inflammatory processes. It is unknown whether Toll-like receptor (TLR)2 acts independently or together with TLR6 in this process. Materials and Methods: The aim of this study was to estimate the relationship between the expressions of TLR2 and TLR6 and the apoptosis of human neutrophils in physiological...

article

P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis

Ming Chen, Jian-Guo Geng

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 2 > 75-84

. Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. Cross-linking of PSGL-1 by P-selectin also primes leukocytes intracellularly...

article

Association of CD45^dimVLA-4⁺ cells with the NKT cell lineage and their selective expression of IL-13, IP-15, and CCR3 transcripts

Agata Matejuk, Michael Afentoulis

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 3 > 183-191

. Introduction Estrogen (E2) was shown to prevent experimental autoimmune encephalomyelitis (EAE) and to produce a novel population of regulatory CD45^dimVLA-4⁺ cells. Although their appearance was dependent upon an elevated hormonal level, E2 was not required for their production, as they also were induced by immunization with Mycobacterium tuberculosis as a component of complete Freund’s adjuvant...

article

Nitric oxide production by pulmonary leukocytes from induced sputum in patients with asthma and its effect on epithelial cell viability

Małgorzata Bieńkowska-Haba, Jerzy Liebhart, Monika Cembrzyńska-Nowak

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 3 > 201-207

. Introduction Nitric oxide (NO) is one of many factors potentially involved in lung remodeling in asthma. The aim of the study was to assess the effect of pulmonary leukocytes from patients with bronchial asthma on alveolar epithelial cell damage in relation to NO production. Materials and Methods Induced sputum samples were obtained from 25 patients with bronchial asthma and 10 healthy volunteers...

article

The use of the Congo red-related dye DBACR to recognize the heavy chain-derived abnormality of myeloma immunoglobulins

Paweł Spólnik, Leszek Konieczny, Barbara Piekarska, Janina Rybarska, more

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 3 > 217-221

. Introduction The aim of this study was to differentiate heavy and light chain-derived instability of monoclonal myeloma immunoglobulins by complexation of matched supramolecular dyes. These are composed of several micellar pieces of self-assembled dye molecules which may penetrate the protein interior of the binding locus with polypeptide chains. These dyes were used to elicit, by precipitation,...

article

ETS transcription factors and regulation of immunity

Sarah Gallant, Gary Gilkeson

Archivum Immunologiae et Therapiae Experimentalis > 2006 > 54 > 3 > 149-163

. The ETS family is a diverse group of transcription factors that control the expressions of genes that participate in an array of cellular activities, ranging from mitosis to apoptosis. As a consequence of regulating these processes, most ETS factors are oncogenic. However, there is growing evidence that ETS factors are also essential to regulation of the immune system. Of the 29 recognized ETS factors,...

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INFLAMMATION (35)
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Archivum Immunologiae et Therapiae Experimentalis

The effect of Chlamydia trachomatis infection of the prostate gland on the concentration of citric acid

Activation of Salmonella-specific immune responses in the intestinal mucosa

Treating autoimmune diseases through restoration of antigen-specific immune tolerance

Regulation of innate and adaptive immune responses by the related cytokines IL-12, IL-23, and IL-27

Routine clinical laboratory tests correspond to increased serum levels of 3-hydroxy fatty acids, markers of endotoxins, in cardiosurgery patients

Regulatory T cells: magic bullets for immunotherapy?

Stem cells in nephrology: present status and future

Therapeutic effects of cisplatin on rat experimental autoimmune encephalomyelitis

Susceptibility of Propionibacterium acnes and Staphylococcus epidermidis to killing by MPO-halide system products. Implication for taurine bromamine as a new candidate for topical therapy in treating acne vulgaris

Elevated TGF-β1 concentration in bronchoalveolar lavage fluid from patients with primary lung cancer

Monoclonal and bispecific antibodies as novel therapeutics

The distinctive role of small heat shock proteins in oncogenesis

The migration of bone marrow-derived non-hematopoietic tissue-committed stem cells is regulated in an SDF-1-, HGF-, and LIF-dependent manner

Novel therapies of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter spp . infections: the state of the art

Toll-like receptors types 2 and 6 and the apoptotic process in human neutrophils

P-selectin mediates adhesion of leukocytes, platelets, and cancer cells in inflammation, thrombosis, and cancer growth and metastasis

Association of CD45^dimVLA-4⁺ cells with the NKT cell lineage and their selective expression of IL-13, IP-15, and CCR3 transcripts

Nitric oxide production by pulmonary leukocytes from induced sputum in patients with asthma and its effect on epithelial cell viability

The use of the Congo red-related dye DBACR to recognize the heavy chain-derived abnormality of myeloma immunoglobulins

ETS transcription factors and regulation of immunity

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