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Protonation constants of protonated monomers and dimers of the vildagliptin are determined potentiometrically. For the low concentration c L = 3.3 mmol dm−3 the monomers L and LH dominate, while for a higher concentration c L = 6.3 mmol dm−3 the dimers L2H2, L2H3, L2H4 and L2H are mainly present. The algorithm used has little influence on the precision of the formation constants in comparison with...
Mixed protonation constants of sitagliptin phosphate at various ionic strengths I (mol kg−1) in range 0.01 and 0.50 and at 298.15 K are determined using FBSTAC4 and HYPERQUAD nonlinear regression analyses of the potentiometric titration curve. At a low concentration c L = 1.1 mmol kg−1 the monomers L, LH, LH2, LH3 and LH4 dominate, while for a concentration range from c L = 13.7 to 24.7 mmol kg−1...
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