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In this paper, a novel tool is introduced for microwave assisted electroporation at 18 GHz, suitable for the integration in a lab-on-a-chip. In contrast to conventional electroporation, microwave electroporation has the advantage of lower field strengths, and can therefore, provide higher cell viability rates. Moreover, with this applicator it is possible to monitor the membrane poration process in...
To enhance the miniaturization of the single-sided resonators, and to overcome the drawbacks in using broadside resonators, the Edge-Coupled Spiral Resonator (EC-SR) is proposed and implemented as near-field sensor. A prototype is fabricated and tested by sensing different liquids and organic tissues. The results validate the possibility to use the proposed resonator in designing sensors for biomedical...
The possibility of monitoring the skull healing after craniotomy using microwaves is studied. The layered head model is constructed using transmission line. The reflected pulse for each layer can then be obtained and is used to monitor the skull healing. The dispersive dielectric profiles for each layer are considered. The simulation results show that the shifts from reflected pulse at skull-brain...
In this paper an image reconstruction system and an algorithm for image reconstruction is developed and studied. The purpose is to determine and optimize a reconstruction scheme that is suitable for microwave imaging of breasts, with the purpose to diagnose breast cancer tumors. The present study is based on data generated from realistic breast models and in particular the use of different matching...
Hyperthermia, increasing tumor temperatures to 40-43°C, is a proven oncological treatment modality enhancing the effectiveness of radiotherapy and chemotherapy. Tumors are usually heated by single radiofrequency or microwave antennas, or arrays of antennas around the patient. Reliable hyperthermia treatment planning by simulation of power and temperature distributions in the patient, requires the...
Hyperthermia, i.e. increasing tumor temperatures to 40–43°C, is a proven treatment modality to enhance the effectiveness of radiotherapy and chemotherapy. Hyperthermia treatment planning focuses on simulation of power and temperature distributions in the patient, as well as optimization of heating patterns. This is a very useful tool with a variety of applications. The last decade substantial progress...
In this contribution, we present broadband microwave measurements on developed biomedical phantom materials. Therefore, we illustrate the reproducible mixing process of the realized phantom materials that are generated in different shapes with a potting compound and barium titanate. Moreover, three microwave measurement systems, including a coaxial probe, a microwave tomography system, and a radar...
In this paper, we present an approach for communication through human body tissue in the R-band frequency range. This study examines the ranges of microwave frequencies suitable for intra-body communication. The human body tissues are characterized with respect to their transmission properties using simulation modeling and phantom measurements. The variations in signal coupling with respect to different...
This work summarizes the results of the multidisciplinary study on applicability of millimeter-wave blood measurements for diagnostic purposes. Here we describe the developed approach to a cellular characterization, the techniques, and key findings of the research. The approach is based on the detecting drug-induced dielectric response of human erythrocytes in parallel with biochemical study of their...
To go toward non-invasive melanoma analysis without the requirement of biopsy, in vitro and in vivo investigations have been performed with near-field microwave sensing techniques. Preliminary dielectric study has been carried out on different types of skin crushes: normal skin and skin with a subcutaneous B16 melanoma tumor. Extracted dielectric properties permits to clearly discriminate the two...
In this work, the first broadband dielectric characterization of African trypanosome parasites from 0.2 to 2.5 THz is presented as a foundation for future sensor applications in the mm- and THz-wave regime. After demonstrating detectability, the complex permittivity of a 5 micrometer thick parasite film is extracted directly from measurements of a terahertz time domain spectrometry setup using a chain...
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