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We describe a Complementary Metal-Oxide Semiconductor (CMOS) Direct Time Interval Measurement (DTIM) Integrated Circuit (IC) to detect the decay (fall) time of the luminescence emission when analyte-sensitive luminophores are excited with an optical pulse. The CMOS DTIM IC includes 14×14 phototransistor array, transimpedance amplifier, regulated gain amplifier, fall time detector, and time-to-digital...
The coagulation and fibrinolytic systems are complex, inter-connected biological systems with major physiological roles. The complex, nonlinear multi-point relationships between the molecular and cellular constituents of two systems render a comprehensive and simultaneous study of the system at the microscopic and macroscopic level a significant challenge. We have created an Agent Based Modeling and...
Continuous glucose monitoring systems are an integral component of diabetes management. Efforts to improve the accuracy and robustness of these systems are at the forefront of diabetes research. Towards this goal, a multi-sensor approach was evaluated in hospitalized patients. In this paper, we report on a multi-sensor fusion algorithm to combine glucose sensor measurements in a retrospective fashion...
A pressure sensor array placed below a mattress can be used to estimate the breathing effort signal unobtrusively. When multiple breathing effort sensor outputs are available, there is sometimes a need to choose the sensor with the best approximation of the actual breathing effort. Previous work with pressure sensor arrays placed on top of or under mattresses used for respiration rate and breathing...
Respiratory gating and tumor tracking are two promising motion-adaptive lung cancer treatments, minimizing incidence and severity of normal tissues and precisely delivering radiation dose to the tumor. Accurate respiration measurement is important in respiratory-gated radiotherapy. Conventional gating techniques are either invasive to the body or bring insufficient accuracy and discomfort to the patients...
This paper introduces a silicon-based imaging array for remote measurements of complex permittivity of tissue. Using a coherent pulsed measurement approach, this time-frequency resolved technique recovers the three dimensional mapping of electrical properties of the subject in the microwave/millimeter-wave frequency spectrum. Some of the major challenges in the design of the system are described....
Magnetic resonance imaging (MRI) is widely used in human breast cancer detection, and the advancement of the radio-frequency (RF) phased-array technology promises to further improve the diagnostic image quality. In this paper, an inverse design method is presented for the theoretical design of an ellipsoidal RF phased array coil for human breast MRI. The target field technique was used to analytically...
In this study, three types of radio-frequency shields are studied and compared in the context of ultra-high field small-animal magnetic resonance imaging. It has been demonstrated that the coil penetration depth and mutual coupling between the coils depend heavily on the type of shield employed. The results were used to guide the design of a 9.4T 8-element transceive small animal array, which provides...
We present a numerical investigation of the RF fields generated inside a human head by single and dual-row loop arrays. For a uniform circular polarization (CP) mode excitation, a dual-row array has no advantage for human brain excitation. Significant improvement of B1+ homogeneity with a simultaneous increase of coverage in the axial direction can be obtained by using a dual-row array together with...
We introduce a fault-tolerant strategy to improve the dependability of a multi-electrode array (MEA), an issue of considerable concern. We propose an interstitial redundancy approach with local reconfiguration. Here spare modules are placed at interstitial sites and can replace neighboring primary modules when they develop faults. We evaluate the performance of such a system under different faults...
Advances in neural electrode technology are enabling brain recordings with increasingly fine spatial and temporal resolution. We explore spatio-temporal (ST) patterns of local field potential spikes using a new high-density active electrode array with 500 μm resolution. We record subdural micro-electrocorticographic (μECoG) signals in vivo from a feline model of acute neocortical epileptiform spikes...
Spatio-temporal dynamics of a mathematical model of myelinated axon in response to staircase-shape extracellular electrical stimulation, which was developed for selective nerve stimulation, is investigated by the computer simulation. It is shown that the response is classified into four types: subthreshold response, cathodic excitation, anodal block and anodal break excitation. Based on the simulation...
Creating high-resolution or high-density, intra-cochlear electrode arrays may significantly improve quality of hearing for cochlear implant recipients. Through focused activation of neural populations such arrays may better exploit the cochlea's frequency-to-place mapping, thereby improving sound perception. Contemporary electrode arrays approach high-density stimulation by employing multi-polar stimulation...
Identifying whether or not a retinal implant has malfunctioned after implantation is crucial for safety and efficacy testing in preclinical animal studies and clinical testing in human volunteers. Technical failure can lead to charge injection to areas other than the retina leading to a misjudgment of safety considerations or psychophysical results. This study assessed the feasibility of using standard...
This pilot study aimed at assessing the feasibility and the effectiveness of an electro Electro-tactile Vestibular Substitution System (EVSS) in patients with unilateral vestibular loss under normal and altered somatosensory conditions from the foot and ankle. Four unilateral vestibular-defective patients voluntarily participated in the experiment. They were asked to stand upright as still as possible...
In this study vibrotactile stimulation of the upper leg and its usability for feedback was tested. Three experiments were performed on ten healthy subjects using pager motors. The first experiment was to test the perception of the vibration at different frequencies and at different locations of the upper leg. The second experiment tested the ability of subjects to estimate location and number of stimuli...
High resolution electrical mapping of slow waves on the stomach serosa has improved our understanding of gastric electrical activity in normal and diseased states. In order to assess the signals acquired from high resolution mapping, a robust framework is required. Our framework is semi-automated and allows for rapid processing, analysis and interpretation of slow waves via qualitative and quantitative...
High resolution mapping of electrical activity is becoming an important technique for analysing normal and dysrhythmic gastrointestinal (GI) slow wave activity. Several methods are used to extract meaningful information from the large quantities of data obtained, however, at present these methods can only be used offline. Thus, all analysis currently performed is retrospective and done after the recordings...
Pattern Reversal (PR) stimulation is a frequently used tool in the evaluation of the visual pathway. The PR stimulus consists of a field of black and white segments (usually checks or bars) of constant luminance, which change phase (black to white and white to black) at a given reversal rate. The Pattern Electroretinogram (PERG) is a biological potential that is evoked from the retina upon viewing...
An immediate need exists for a portable diagnostic device for the assessment of cortical function, and diagnosis of mTBI. This paper presents initial results using a vibrotactile acuity test for the objective and quantitative diagnosis of acute mTBI suspects. mTBI is hypothesized to involve derangement or damage to the underlying cortical network. In particular, fundamental building blocks of the...
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