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Contrast in optical coherence tomography (OCT) images is often limited, particularly when pathological tissue is morphologically or optically similar to normal tissue. In recent years, there has been increasing interest in developing methods for enhancing OCT contrast. In general, contrast can be enhanced by the administration of passive or targeted exogenous contrast agents, or by exploiting linear...
Contrast in optical coherence tomography (OCT) images is often limited, particularly when pathological tissue is morphologically or optically similar to normal tissue. In recent years, there has been increasing interest in developing methods for enhancing OCT contrast. In general, contrast can be enhanced by the administration of passive or targeted exogenous contrast agents, or by exploiting linear...
Conventional histologic techniques cannot readily be used for 3D reconstruction of large tissue volumes. We have developed an imaging rig which supports both confocal and light microscopy, and utilizes a surface imaging approach to serially image embedded tissue blocks while maintaining alignment and registration of the image series
Conventional histologic techniques cannot readily be used for 3D reconstruction of large tissue volumes. We have developed an imaging rig which supports both confocal and light microscopy, and utilizes a surface imaging approach to serially image embedded tissue blocks while maintaining alignment and registration of the image series
Previously, we introduced a new harmonic motion imaging (HMI) technique for simultaneous monitoring and generation of ultrasound therapy treatment using a single element focused-ultrasound and one pulse-echo transducer. The new HMI technique uses an amplitude-modulated beam (instead of using two beams) that has a stable focal zone for the applied harmonic radiation force. The harmonic radiation force...
Previously, we introduced a new harmonic motion imaging (HMI) technique for simultaneous monitoring and generation of ultrasound therapy treatment using a single element focused-ultrasound and one pulse-echo transducer. The new HMI technique uses an amplitude-modulated beam (instead of using two beams) that has a stable focal zone for the applied harmonic radiation force. The harmonic radiation force...
Current density imaging (CDI) is a technique that uses magnetic resonance imaging (MRI) to measure the distribution of externally applied electric current inside tissues. However, GDI processing is rendered inaccurate by the distortion caused by the nonlinearity of MRI gradient fields. The distortion interferes with the proper registration and the curl operation required for correct computation of...
Current density imaging (CDI) is a technique that uses magnetic resonance imaging (MRI) to measure the distribution of externally applied electric current inside tissues. However, GDI processing is rendered inaccurate by the distortion caused by the nonlinearity of MRI gradient fields. The distortion interferes with the proper registration and the curl operation required for correct computation of...
This paper presents a parallel-computing FDTD simulator for electromagnetic analysis and design applications in Magnetic Resonance Imaging system. It is intended to be a complete, high-performance FDTD model of an MRI system including all temporal RF and low-frequency field generating units and electrical models of the patient. The developed MRI-dedicated FDTD algorithm is adapted to a parallel computing...
This paper presents a parallel-computing FDTD simulator for electromagnetic analysis and design applications in Magnetic Resonance Imaging system. It is intended to be a complete, high-performance FDTD model of an MRI system including all temporal RF and low-frequency field generating units and electrical models of the patient. The developed MRI-dedicated FDTD algorithm is adapted to a parallel computing...
A mathematical model of whole-body metabolism is developed to predict glucose homeostasis during exercise by using a hormonal controller over cellular metabolic processes. Model simulations were validated with experimental data from exercise studies in humans. The exercise-induced changes in hormonal signals modulated metabolic flux rates of various tissues in a coordinated way to maintain blood glucose...
A mathematical model of whole-body metabolism is developed to predict glucose homeostasis during exercise by using a hormonal controller over cellular metabolic processes. Model simulations were validated with experimental data from exercise studies in humans. The exercise-induced changes in hormonal signals modulated metabolic flux rates of various tissues in a coordinated way to maintain blood glucose...
This document describes the effects of several design parameters on the traction generated by the suction pads of a mobile robot that walks on the surface of the heart. HeartLander is a miniature mobile robot that adheres to the epicardial surface of the heart using suction, and can travel to any desired location on the heart to administer therapeutic applications. To maximize the effectiveness of...
This document describes the effects of several design parameters on the traction generated by the suction pads of a mobile robot that walks on the surface of the heart. HeartLander is a miniature mobile robot that adheres to the epicardial surface of the heart using suction, and can travel to any desired location on the heart to administer therapeutic applications. To maximize the effectiveness of...
"Unequal anisotropy ratios" is an important property of cardiac tissue. Many of the fundamental mechanisms governing how the heart responds to an electrical shock require unequal anisotropy ratios. In this paper, author explains the role of unequal anisotropy ratios using pictures rather than mathematics. The goal is to develop physical insight, so has to understand qualitatively why the...
"Unequal anisotropy ratios" is an important property of cardiac tissue. Many of the fundamental mechanisms governing how the heart responds to an electrical shock require unequal anisotropy ratios. In this paper, author explains the role of unequal anisotropy ratios using pictures rather than mathematics. The goal is to develop physical insight, so has to understand qualitatively why the...
A new transient finite element model of extracellular action potentials recording with a microelectrode in a tissue slice is presented. The neuron model is based on the Hodgkin-Huxley equations implemented with a thin film approximation of the neuron membrane. The computations of the membrane potential and currents, as well as that of the intra and extracellular potential fields, are performed at...
A new transient finite element model of extracellular action potentials recording with a microelectrode in a tissue slice is presented. The neuron model is based on the Hodgkin-Huxley equations implemented with a thin film approximation of the neuron membrane. The computations of the membrane potential and currents, as well as that of the intra and extracellular potential fields, are performed at...
Two types of intracortical multichannel flexible neural probes coated with a hybrid biodegradable polymer were designed and fabricated. The hybrid biodegradable polymer was made of polyethylene glycol and biodegradable polymeric microspheres containing nerve growth factor (NGF) and incorporated to improve the stiffness for flexible neural probe insertion, and promote regrowth of damaged neural tissues...
Two types of intracortical multichannel flexible neural probes coated with a hybrid biodegradable polymer were designed and fabricated. The hybrid biodegradable polymer was made of polyethylene glycol and biodegradable polymeric microspheres containing nerve growth factor (NGF) and incorporated to improve the stiffness for flexible neural probe insertion, and promote regrowth of damaged neural tissues...
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