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Hospitals and manufacturers are designing and deploying the IEEE 802.x wireless technologies in medical devices to promote patient mobility and flexible facility use. There is little information, however, on the reliability or ultimate safety of connecting multiple wireless life-critical medical devices from multiple vendors using commercial 802.11a, 802.11b, 802.11g or pre-802.11n devices. It is...
A method of ranking devices for replacement has been successfully trialled at Flinders Medical Centre (FMC). Software developed by Flinders Biomedical Engineering (see wwwjbe.org.au) has been distributed to a network of device managers throughout FMC for the entry of easily determined parameters which relate to the likelihood of a device problem occurring and to the consequence of the problem. Algorithms...
An international survey was conducted in 2003 to assess the status of clinical engineering services delivered to hospitals in developing countries. Data was collected from Asia, Africa, Latin America and Mexico. The responses were compared to two previous studies done in industrialized countries. A model of medical technology acquisition and diffusion is presented
The purpose of this project was to design and implement a computerized maintenance management system (CMMS) to be used at the Chilean Naval Hospital Biomedical Engineering Department. It is designed to meet the specific needs of this military facility and follows the generic clinical engineering maintenance management system suggested by Association for the Advancement of Medical Instrumentation (AAMI)
Wireless medical device network (WMDN) deployment is occurring to facilitate ambulatory patient care, increase safer and more intelligent diagnostic and therapeutic capabilities, and improve flexible patient bed configuration that matches census requirements. Patient safety risks exist from delayed or lost WMDN alarm and data streams, however, and non-proprietary verification and validation (V2) techniques...
Safe use of medical devices is a comprehensive concept with its technical integration. It includes not only its procedural operations but also its vigilance to patient status, correct installation of device, proper user's education and training, appropriate device maintenance, user facility compatibility, and acceptable interference from environment. Consequently, in technology advanced countries,...
Appropriate deployment of technological innovation contributes to improvement in the quality of healthcare delivered, the containment of cost, and access to the healthcare system. Hospitals have been allocating a significant portion of their resources to procuring and managing capital assets; they are continuously faced with demands for new medical equipment and are asked to manage existing inventory...
Because of the overwhelming scattering of light in biological tissues, the spatial resolution and imaging depth of conventional fluorescent imaging is unsatisfactory. Therefore, we present a dual modality imaging technique by combining fluorescence imaging with high-resolution noninvasive photoacoustic tomography (PAT) for the study of an animal tumor model. PAT provides high-resolution structural...
A 3D reconstruction microscope has been built in order to investigate the structural details of the airway tree and the vasculature of mouse lungs. The objective is to create an anatomically correct finite element model of a mouse lung in order to validate results from simulations obtained using an existing model of the human lung. The 3D reconstruction microscope consists of a fully automated scanning...
We developed a reflectance continuous-wave near-infrared spectroscopy topography system with multi-source and multi-detector sensor head. A single wavelength (808 nm) laser diode is used as the original light source. With different-measurement approach, we can reconstruct images representing the variety of cerebral blood volume in clinical applications. Phantom experiments have been taken to verify...
We used sub-terahertz (THz) imaging to exam two cross sections of epithelial cancer tissue embedded in paraffin using a 0.19 THz electromagnetic wave. The sub-THz imaging system was constructed with a tunnel injection transit time (TUNNETT) diode, a Schottky barrier diode detector and a X-Z stage. We examined the difference between a sub-THz wave absorption in melanoma and nevus tissue
Optical methods from the near infrared range, in particular the time resolved near infrared spectroscopy offer a new non-invasive, real-time technique for monitoring of the blood perfusion and oxygenation in living tissue. The principle and instrumentation of the time resolved optical spectroscopy system for cerebral oxygenation imaging have been described. The system consists of two semiconductor...
Small animal imaging systems now allow researchers to non-invasively monitor the progression of diseases in living small animals and study the efficacy of drugs and treatment protocols. Magnetic resonance imaging (MRI) is an established imaging modality capable of obtaining high resolution anatomical images which are sensitive to blood volume, blood flow, and metabolic rate of oxygen. Optical tomography,...
High-intensity focused ultrasound (HIFU) has become a viable alternative for treatment of primary and metastatic liver tumors. We evaluated the effects of presence of a large blood vessel and its distance to the tumor on lesion size during HIFU heating. A finite element method (FEM) was used to obtain the temperature distribution for a transfer equation based on large blood vessels convection effect...
By cutting a spherical focused transducer into two coaxial and confocal transducer elements, a confocal complex transducer used in dual-frequency HIFU system was obtained. The lesion induced by dual-frequency HIFU in freshly excised porcine livers were obviously larger than that induced by conventional single-frequency HIFU at the same exposure conditions. The experiment results have also shown that...
We proposed novel depth-controlled photodynamic therapy (PDT) by varying pulsed laser irradiation condition. We focus on photocytotoxicity suppression under high peak power pulsed irradiation to apply this phenomenon to surface intact therapy to preserve healthy wall of a hollow organ. The relation between laser irradiation condition and cell lethality of rat prostate cancer cell with PDT using practical...
This paper discusses new methods to control the heating pattern of the prototype resonant cavity applicator for deep tumor hyperthermia treatment. We have already confirmed the effectiveness of the developed heating system with experiments using agar phantoms and computer simulations. Here, the following two methods to control the heating pattern were proposed. In the first method, a human body, which...
Recent improvements in the accessibility of high-throughput genotyping have brought a great deal of attention to disease association and susceptibility studies. This paper explores possibility of applying combinatorial methods to disease susceptibility prediction. The proposed combinatorial methods as well as standard statistical methods are applied to publicly available genotype data on Crohn's disease...
We present a strategy of bioinformatics analysis to exploit the current data available both on genomic and metabolic levels and integrate these at novel levels of understanding of metabolic disorders. PathAligner is applied to predict biomedical data based on a given disorder. A case study on urea cycle disorders is demonstrated. Both genetic data and metabolic information are retrieved. We integratively...
This paper introduced a straightforward and effective chromatographic data pre-processing method developing for utilization prior to chemometric analysis of large metabonomic dataset arising from high performance liquid chromatography. Nucleotides chromatographic fingerprinting in human urines was employed to validate the proposed method. Performance for discrimination cancer samples from healthy...
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