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This paper describes an electrical model of the ventricles incorporating real geometry and motion. Cardiac geometry and motion is obtained from segmentations of multiple-slice MRI time sequences. A static heart model developed previously is deformed to match the observed geometry using a novel shape registration algorithm. The resulting electrocardiograms and body surface potential maps are compared...
A semi-automatic multiple-stage segmentation scheme of brainstem and cerebellum is proposed in this paper. This proposed scheme contains a modified scale-based fuzzy connectedness (FC) algorithm, a morphology operator, Chain code, and active contour mode (ACM). A modified scale-based FC is utilized to delivery a rough segmentation, a morphology operator and Chain code are used to compensate the uncompleted...
The use of two powerful classification techniques (boosting and SVM) is explored for the segmentation of white-matter lesions in the MRI scans of human brain. Simple features are generated from proton density (PD) scans. Radial basis function (RBF) based Adaboost technique and support vector machines (SVM) are employed for this task. The classifiers are trained on severe, moderate and mild cases....
In vivo small animal imaging provides a powerful tool for the study of a variety of diseases. Magnetic resonance imaging (MRI) has become an established technology for the assessment of therapies. In this study, we used high-resolution MRI to evaluate polycystic kidney disease (PKD) in transgenic mice. We used a customized mouse coil to acquire serial MR images from both wide-type and transgenic PKD...
Recent advances in medical imaging have resulted in the introduction of dual-modality scanners which can simultaneously acquire two independent imaging modalities, such as positron emission tomography (PET) and computed tomography (CT) image data in a single session. These multi-dimensional PET-CT data contain both the functional and anatomical information of the human body, thus, providing the ability...
The accurate segmentation of the teeth from the triangle mesh is an important step in computer-aided orthodontic. Because teeth come in different shapes and their arrangements vary substantially from one individual to another, tooth segmentation is difficult. This paper proposes a new method to accurately segment the teeth interactively. Based on curvature values of the triangle mesh, feature points...
In the diagnosis and therapy of prostate cancer, it is critical to measure the volume of the prostate and locate its boundary. Three-dimensional transrectal ultrasound (3D TRUS) imaging has been demonstrated to be a useful technique to perform such a task. Due to image speckle as well as low contrast in ultrasound images, segmentation of the prostate in 3D US images is challenging. In this paper,...
We have been developing a computer-aided diagnosis (CAD) system for distinguishing the cirrhosis in MR images by shape and texture analysis. Two shape features are calculated from a segmented liver region, and seven texture features are quantified by using grey level difference method (GLDM) within the small region-of-interests (ROIs). The degree of cirrhosis is derived from integrating the shape...
Invasive intracranial electroencephalography (EEG) studies help identify the epileptogenic focus and assess if the identified zone overlies eloquent cortex by means of cortical stimulation. Proper interpretation and use of the intracranial recording/stimulation studies requires an effective display of multimodal information. We developed a software system which can combine the patient's segmented...
In patients suffering from various sleep disorders and some elderly patients, sleep is disturbed with frequent but brief arousal. These events do not cause behavioral awakening, but can lead to excessive day time sleepiness. These brief arousals or microarousals (MAs) can be identified on a standard polysomnogram as a transient abrupt change of frequency, typically in the alpha and extended beta (16-40...
Perfusion magnetic resonance imaging (pMRI) is an important tool to assess tumor angiogenesis for the early detection of lung cancer. This paper presents a novel integrated framework for spatio-temporal modeling of pulmonary nodules in pMRI image sequences. After localizing a nodule region in each image, we perform segmentation in the region to extract nodule boundary, and then use thin-plate spline...
The automated extraction of brain vessels from magnetic resonance angiography (MRA) has found its applications in vascular disease diagnosis, endovascular operation and neurosurgical planning. In this paper we first present a concise technical review on cerebral vasculature extraction from MRA. It reveals the latest development in the area of vessel extraction. Then we detail the main challenges to...
A new cryosection milling imaging system with high spatial resolution is developed to screen small laboratory animals such as mice and rats. The system hardware consists of cutting device, image capture and photography device, refrigerated storage and parallel data processing system. By this system high spatial resolution (no less than 20 mum) small laboratory animal atlas can be achieved. After image...
This paper presents a method to segment brain tissue from T1-weighted magnetic resonance (MR) images. A modified BayesShrink method is utilized to filter the image in wavelet transform domain before segmentation, where the shrinkage strength is automatically adjusted with respect to noise level. Then the fuzzy c-means clustering is applied to segment brain tissue into cerebrospinal fluid, gray matter...
In this paper we present an algorithm as the combination of a low level morphological operation and model based global circular shortest path scheme to explore the segmentation of the right ventricle. Traditional morphological operations were employed to obtain the region of interest, and adjust it to generate a mask. The image cropped by the mask is then partitioned into a few overlapping regions...
The article presents a concept of balance among image points based on the correlation of points and then develops a new binarization method for gray scale image, which can be used in vessel extraction of DSA images. A point is in balance only when its resistance counteracts the influence from the neighborhood, while noise breaks down such balance. By restoring the balance of every single point, the...
The development techniques of implementation of converting the medical slice images to 3-D finite element grids are discussed, and an integrated system based on ITK and VTK is built. The system can provide a series of functions including image reading, reduction, segmentation, reconstruction and finite element grids generation with flexible user's graphics interface. At same time, this system can...
A new segmentation algorithm based on image algebraic operations for background removal of the Visible Human Data (VHD) has been proposed in the paper. The new algorithm has been implemented and tested. Both algorithm analysis and testing results have showed that the new algorithm could have better segmentation results on the VHD, with less algorithmic complexity and less computational complexity,...
Breast thermography is considered particularly valuable for early breast tumors detection. The fast growing tumor has a higher metabolic rate and associated increase in local vascularization. It will cause the occurrence of some asymmetric heat patterns. Clinical interpretation of a breast thermogram is primarily based on the asymmetry analysis of these heat patterns visually and subjectively. In...
Nanometer-sized particles such as luminescent quantum dots (QDs) and energy-transfer nanoparticles have unique optical, electronic, and structural properties (e.g., signal brightness, photostability, and multicolor light emission) that are not available from traditional organic dyes and fluorescent proteins. Here we report the use of color-coded nanoparticles and dual-color fluorescence correlation...
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