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Alteration of neuron structure can induce abnormalities in signal propagation for nervous systems, as seen in traumatic brain injuries, damage and tumours. Here, effects of geometrical changes and damage of neuron structure are investigated in two scaled nerve bundle models, made of myelinated and unmyelinated nerve fibres. We propose a 3D finite element model of a nerve bundle as a unique framework...
Migraine is a socioeconomic burden, whose pharmaceutical and invasive treatment methods may have troublesome side-effects. A wearable neuromodulator targeting frontal nerve branches of trigeminal nerve may provide an effective solution to suppress or treat migraine. Such solutions have had limited efficacies. In this paper, using computational models, the relationship of this lack of efficacy to some...
Transcutaneous Electrical Nerve Stimulation (TENS) attracts extensive attention in neuromodulation due to its minimal invasiveness. Conventional TENS uses non-invasive surface planar electrodes attached to the skin for delivering the stimulation current to modulate neural circuitries. Previous studies have shown that using these surface planar electrodes in TENS therapy may cause stimulation-induced...
Traumatic brain injuries and damage are major causes of death and disability. Whereas recent experimental evidence has uncovered mechanical phenomena accompanying the neural activity, the mechanism by which mechanical impact affects neuronal impairment remains unclear. We propose a 3D model of a nerve bundle to understand the electrophysiological changes due to trauma. Here, the electrical and mechanical...
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