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Alteration of neuron structure can induce abnormalities in signal propagation for nervous systems, as seen in traumatic brain injuries, damage and tumours. Here, effects of geometrical changes and damage of neuron structure are investigated in two scaled nerve bundle models, made of myelinated and unmyelinated nerve fibres. We propose a 3D finite element model of a nerve bundle as a unique framework...
Dual tasking refers to the simultaneous execution of two tasks with different demands. In this study, we aimed to investigate the effect of a second task on a main task of motor execution and on the ability to detect the cortical potential related to the main task from non-invasive electroencephalographic (EEG). Participants were asked to perform a series of cue-based ankle dorsiflexions as the primary...
A 16-channel implantable microelectrode array (MEA) was designed and fabricated by Micro-electromechanical Systems (MEMS) technology. Then the electrode sites were modified with platinum/graphene oxide nanocomposites (Pt-GO) by one-step electrochemical deposition and later handled by cyclic voltammetry reduction in phosphate buffer solution. Finally, a Nafion thin film was coated on the MEA surface...
Migraine is a socioeconomic burden, whose pharmaceutical and invasive treatment methods may have troublesome side-effects. A wearable neuromodulator targeting frontal nerve branches of trigeminal nerve may provide an effective solution to suppress or treat migraine. Such solutions have had limited efficacies. In this paper, using computational models, the relationship of this lack of efficacy to some...
Visual prosthesis based on penetrative optic nerve (ON) stimulation is an alternative approach to partially restore visual function. As one of the most important factors, pulse shape of electrical stimulus is a major consideration in the design of ON visual prosthesis. Animal experiments showed that the evoked responses in visual cortex (V1) to ON electrical stimulation are dependent on the stimulus...
In order to understand brain mechanisms and functionalities, neural probes with electrode arrays are incorporated into mice and Local Field Potentials (LFP) are recorded indicating the activities of groups of neurons. Next, the brain activity can be analyzed in terms of Current Source Density (CSD), which are computed via the LFP. In this paper, we propose the analysis of the somatosensory cortex...
Deep brain stimulation (DBS) is a common therapy for the treatment of essential tremor (ET). Currently, this technology continuously delivers stimulation to deep brain regions to mitigate symptoms. Closed-loop DBS aims to deliver stimulation only when symptoms are present, thus improving battery life and decreasing potential side effects. In this study, we used an investigational DBS device implanted...
In this paper, the interaction between axons in nerve trunks has been characterized in the statistical sense while the mechanism model is investigated based on two different observation scales. In order to describe the interaction phenomena, a symmetric coupling factor matrix has been presented which is considered as a transverse mode combining the standard cable equation. It has been shown that the...
Traumatic brain injuries and damage are major causes of death and disability. Whereas recent experimental evidence has uncovered mechanical phenomena accompanying the neural activity, the mechanism by which mechanical impact affects neuronal impairment remains unclear. We propose a 3D model of a nerve bundle to understand the electrophysiological changes due to trauma. Here, the electrical and mechanical...
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