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Cortical thickness estimation performed in vivo via magnetic resonance imaging (MRI) is an important technique for the diagnosis and understanding of the progression of Alzheimer's disease (AD). Directly using raw cortical thickness measures as features with Support Vector Machine (SVM) for clinical group classification only yields modest results since brain areas are not equally atrophied during...
Similarity in appearance between various skin diseases, often makes it challenging for clinicians to identify the type of skin condition, and the accuracy is highly reliant on the level of expertise. There is also a great degree of subjectivity and inter/intra observer variability found in the clinical practices. In this paper, we propose a method for automatic skin diseases recognition that combines...
Adrenal lesions include a wide variety of benign and malignant neoplasms of the adrenal gland, and are seen in up to 5% of computed tomography (CT) examinations of the abdomen. Better identification of these lesions is important for effective management and patient prognosis. Detection on low-contrast CT images, however, even for experienced physicians can be difficult and error-prone, because the...
Histopathology image classification can provide automated support towards cancer diagnosis. In this paper, we present a transfer learning-based approach for histopathology image classification. We first represent the image feature by Fisher Vector (FV) encoding of local features that are extracted using the Convolutional Neural Network (CNN) model pretrained on ImageNet. Next, to better transfer the...
1p/19q co-deletion is an important prognostic factor in low grade gliomas. However, determination of the 1p/19q status currently requires a biopsy. To overcome this, we investigate a radiogenomic classification using support vector machines to non-invasively predict the 1p/19q status from multimodal MRI data. Different approaches of predicting this status were compared: a direct approach which predicts...
A panoramic radiography image provides not only details of teeth but also rich information about trabecular bone. Recent studies have addressed the correlation between trabecular bone structure and osteoporosis. In this paper, we collect a dataset containing 40 images from 40 different subjects, and construct a new methodology based on a two-stage classification framework that combines multiple trabecular...
Task-based functional magnetic resonance imaging (tfMRI) is widely used to localize brain regions or networks in response to various cognitive tasks. However, given two groups of tfMRI data acquired under distinct task paradigms, it is not clear whether there exist intrinsic inter-group differences in signal composition patterns, and if so, whether these differences could be used for data discrimination...
Detection of brain metastases in patients with undiagnosed primary cancer is unusual but still an existing phenomenon. In these cases, identifying the cancer site of origin is non-feasible by visual examination of magnetic resonance (MR) images. Recently, radiomics has been proposed to analyze differences among classes of visually imperceptible imaging characteristics. In this study we analyzed 46...
In this study, a novel feature selection framework is proposed to simultaneously perform classification and clinical scores prediction of Parkinson's disease (PD) via multi-modal neuroimaging data. Specifically, a new feature selection model is devised to capture discriminative features to train support vector regression model for clinical scores (e.g., sleep scores and olfactory scores) prediction...
In clinical practice, the magnetic resonance imaging (MRI) is a prevalent neuroimaging technique for Alzheimer's disease (AD) diagnosis. As a learning using privileged information (LUPI) algorithm, SVM+ has shown its effectiveness on the classification of brain disorders, with single-modal neuroimaging samples for testing but multimodal neuroimaging samples for training. In this work, we propose to...
Dermoscopy image is usually used in early diagnosis of malignant melanoma. The diagnosis accuracy by visual inspection is highly relied on the dermatologist's clinical experience. Due to the inaccuracy, subjectivity, and poor reproducibility of human judgement, an automatic recognition algorithm of dermoscopy image is highly desired. In this work, we present a hybrid classification framework for dermoscopy...
Neurodegenerative pathologies, such as Alzheimer's disease, are linked with morphological alterations and tissue variations in sub-cortical structures which can be assessed from medical imaging and biological data. In this work, we present an unsupervised framework for the classification of Alzheimer's disease (AD) patients, stratifying patients into four diagnostic groups, namely: AD, early Mild...
Histopathology forms the gold standard for confirmed diagnosis of a suspicious hyperplasia being benign or malignant and for its sub-typing. While techniques like whole-slide imaging have enabled computer assisted analysis for exhaustive reporting of the tissue section, it has also given rise to the big-data deluge and the time complexity associated with processing GBs of image data acquired over...
Functional and structural connectivity convey different information about the brain. The integration of these different approaches is receiving growing attention from the research community, as it can shed new light on brain functions. This manuscript proposes a constrained autoregressive model with different lag-orders generating an “effective” connectivity matrix which models the structural connectivity...
Human brain connectomics is a rapidly evolving area of research, using various methods to define connections or interactions between pairs of regions. Here we evaluate how the choice of (1) regions of interest, (2) definitions of a connection, and (3) normalization of connection weights to total brain connectivity and region size, affect our calculation of the structural connectome. Sex differences...
Action recognition systems have the potential to support clinicians, coaches and physical therapists in identifying important adopted movement patterns which could aid injury detection potential or inform rehabilitation strategies. Currently, motion capture systems, structured light pattern and time-of-flight sensors have utilization limitations that place constraints on their use outside of the laboratory...
Age-related macular degeneration (AMD) is a major cause of irreversible blindness and loss of vision in people over 50 years old. Fluid (or cyst) regions such as intraretinal fluid (IRF), subretinal fluid (SRF), and sub-retinal pigment epithelium (sub-RPE), have different tissue appearance in Optical Coherence Tomography (OCT) images compared to normal retina tissue and are a defining feature of AMD...
Detection of infarcted myocardium in the left ventricle is achieved with delayed enhancement magnetic resonance imaging (DE-MRI). However, manual segmentation is tedious and prone to variability. We studied three texture analysis methods (run-length matrix, co-occurrence matrix, and autoregressive model) in combination with histogram features to characterize the infarcted myocardium. We evaluated...
In computerized detection of clustered microcalcifications (MCs) from mammogram images the occurrence of false positives (FPs) varies greatly from case to case. In this work, we develop a probabilistic modeling approach to estimate the number of individual FPs present in a detected MC lesion. We describe the number of true positives (TPs) by a Poisson-Binomial probability distribution, wherein a logistic...
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