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We present an interactive approach to train a deep neural network pixel classifier for the segmentation of neuronal structures. An interactive training scheme reduces the extremely tedious manual annotation task that is typically required for deep networks to perform well on image segmentation problems. Our proposed method employs a feedback loop that captures sparse annotations using a graphical...
Cell detection in microscopy images is a common and challenging task. We propose a new approach for mitotic cell detection in histopathology images, which is based on a Deep Residual Network architecture combined with Hough voting. We propose a voting layer for neural networks and introduce a novel loss function. Our approach is learned from scratch using cell centroids and the original images. We...
Cervical nuclei carry substantial diagnostic information for cervical cancer. Therefore, in automation-assisted reading of cervical cytology, automated and accurate segmentation of nuclei is essential. This paper proposes a novel approach for segmentation of cervical nuclei that combines fully convolutional networks (FCN) and graph-based approach (FCNG). FCN is trained to learn the nucleus high-level...
In this paper, we present a novel deep learning model termed Deep Autoencoding-Classification Network (DACN) for HEp-2 cell classification. The DACN consists of an autoencoder and a normal classification convolutional neural network (CNN), while the two architectures shares the same encoding pipeline. The DACN model is jointly optimized for the classification error and the image reconstruction error...
We propose a novel multiple-input multiple-output convolution neural network (MIMO-Net) for cell segmentation in fluorescence microscopy images. The proposed network trains the network parameters using multiple resolutions of the input image, connects the intermediate layers for better localization and context and generates the output using multi-resolution deconvolution filters. The MIMO-Net allows...
Analysis and interpretation of stained tumor sections is one of the main tools in cancer diagnosis and prognosis, which is mainly carried out manually by pathologists. The avent of digital pathology provides us with the challenging opportunity to automatically analyze large amounts of these complex image data in order to draw biological conclusions from them and to study cellular and tissular phenotypes...
Quantitative analysis of vesicle-plasma membrane fusion events in the fluorescence microscopy, has been proven to be important in the vesicle exocytosis study. In this paper, we present a framework to automatically detect fusion events. First, an iterative searching algorithm is developed to extract image patch sequences containing potential events. Then, we propose an event image to integrate the...
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