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Ribonuclease 3 (RNase3) is a member of the human RNaseA superfamily. It is led by a 27-residue signal peptide and secreted into body fluid to eliminate the infection of microbial pathogens in innate immune systems. The signal peptide of RNase3 (RNase3sp) not only directs protein secretion via endoplasmic reticulum (ER) and Golgi apparatus, but also its N-terminal 17 amino acid residues (RNase3sp1-17)...
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