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We have developed a hybrid optical tomography system combing optical coherence tomography (OCT) and line-scanning fluorescence laminar optical tomography (FLOT). This system could be used for concurrent depth-resolved tissue-structural and molecular imaging.
We demonstrate the advantage of combining high-resolution Fourier domain optical coherence tomography (OCT) with wide-field time-gated fluorescence lifetime imaging microscopy (FLIM) for a comprehensive morphological and biochemical characterization of atherosclerotic vulnerable plaques (VP).
Efficient broadband spectrum oscillation was obtained directly from a laser-diode-pumped Kerr-lens mode-locked Yb:YAG laser with intracavity nonlinear media. The spectrum was expanded to around 1040 nm to 1070 nm. The spectrum is much broader than the fluorescence spectrum at 1050 nm.
We present the first observation of cryogenic operation in an all-solid-state refrigerator. A temperature drop of ~150 K is demonstrated in a 0.2 cm3 rare-earth doped fluoride crystal (Yb:YLF) using anti-Stokes fluorescence, at a record cooling power of 110 mW. Lowest electronic transition within Yb3+ Stark manifold along with cavity enhanced absorption and thermal-load management were key in achieving...
We propose a method to improve depth resolution and accuracy of fluorescent molecular tomography (FMT) by applying a spatial constraint to obtain a low-resolution fluorophore presence map. Results are verified using a CW FMT system.
We report detailed spectral and spatial characterization of a 0.1-MeV-0.8 MeV tunable ultra-bright laser-based Compton scattering source. Nuclear Resonance Fluorescence experiments with the source are also presented.
Through systematic experiments and stochastic modeling we demonstrate that cell motility can be guided by optical torques exerted by the light polarization. This torque affects the actin network which is responsible for cell's movement.
We report the observation of up to 5 Rabi cycles in a single molecule. A pi-pulse excitation is achieved with 500 photons, marking an important step towards preparation of coherent superposition states with few photons.
We report elliptically-polarized fluorescence from colloidal semiconductor quantum dots in a chiral 1-D photonic bandgap microcavity composed of a planar-aligned cholesteric liquid crystal. Antibunched fluorescence proves a polarized single photon source operating at room temperature.
Fluorescence imaging with resolution ten times better than the diffraction limit in three dimensions over a depth of field of 2 mum is demonstrated with a widefield microscope that exhibits a double-helix point spread function.
We present a novel technique for measuring the characteristics of a cloud of cold atoms by monitoring the spontaneous emission coupled into the guided mode of a nanofiber. We show that the fiber is very sensitive to the atoms close to its surface.
The effect of dispersion of the excitation pulse in two-photon microscopy is examined with a photon-counting microscope in both stationary and scanning modalities, and it is demonstrated that transform-limited pulses provide the best signal yield despite increased bleaching rates.
Surface-plasmon-polariton-enhanced fluorescence from CdSe/ZnS quantum dots (QD) deposited onto patterned gold/PMMA substrates has been observed, and the enhancement related to QD position with regard to the type of surface and nanostructures.
An endomicroscope with enhanced signal collection efficiency was developed using customized double-clad fiber and aspherical compound-lens. Ex vivo two-photon fluorescence imaging of epithelial tissues was demonstrated for the first time with an all-fiber-optic scanning endomicroscope.
We demonstrate a silicon diffractive element that serves as an optical tweezer in the near infrared and as a fluorescence collector in the visible. The 1.3 NA lens is achromatic and has high diffraction efficiency.
Effects of gas-phase collisions on active optical sensing and use of picosecond laser spectroscopy for their characterization are reviewed. Additionally, novel time-resolved approaches to reduce collisional sensitivity and to exploit species-dependent collision rates are discussed.
Vacuum ultraviolet fluorescence from micro-pulling down method-grown Er:LiCAF is found to have 163-nm peak emission with 1.3-mus lifetime, making it one of the shortest emission wavelengths from solid-state materials reported.
Phonon-assisted anti-Stokes fluorescence has been observed in GaN film grown on Si (111) substrate. The donor-acceptor pairs and bound excitons have played primary roles in the generation of anti-Stokes fluorescence.
We present a procedure for simultaneous optimization of efficiency-bandwidth product and superfluorescence noise suppression in ultrabroadband high-energy optical parametric chirped pulse amplification. Gain dependence of parameters makes stage-by-stage signal chirp optimization necessary in multi-stage amplification.
We demonstrate a bright, bandwidth-engineerable, compact, quasi-phase-matched single-waveguide source generating photon pairs near 900 nm and 1300 nm. Coincidence spectra are measured for a periodically-poled KTiOPO4 waveguide for both type-0 and type-I spontaneous parametric down-conversion.
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