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Commonly, microelectrodes used in microfluidics are made from copper, Au or Pt. They are difficult to fabricate and the cost is relatively high. Thus, we designed and fabricated a novel microelectrode made from silicon for it is cheap and easy to fabricate. It has been proven that cells can be manipulated by dielectrophoresis force producing on interdigitated electrodes. In addition, the direction...
Ultra-sensitive mass sensor is demanded for bio/chemical molecular detection. A piezoresistive resonant cantilever sensor with optimized is developed with an optimized electromagnetic excitation for high-mode flexure resonance. In our experiment, it has been proved that the quality factor of the resonant sensor can be improved by this optimized high-mode resonance exciting technique. Experimental...
In this study, basing on electrochemistry and MEMS technology we develop a novel biosensor with multi channels to detect three markers (hyaluronic acid (HA), Laminin (LN), type IV collagen (IV-C) ) so as to evaluate the liver disease. With MEMS technology, a chip including a CE, a RE and 6 gold electrodes is fabricated for detection of at most 6 markers simultaneously. Different antibodies of serum...
Dielectrophoretic concentrators were successfully developed on a EWOD-based chip. In such a chip, two major electrokinetic forces were exerted on objects on different scales. EWOD is used to pump droplets on a mm scale, while DEP manipulates bio-particles on a mum scale. Both cells and polystyrene beads were used to demonstrate the concentration abilities by pDEP and nDEP forces, respectively. Since...
5SPE (Solid phase extraction) method, which is compatible with MEMS (micro-electro-mechanical system) technology, has proven efficient and amenable to microfluidic chips. An SPE microfluidic chip for DNA extraction by using porous silicon dioxide as the solid phase matrix has been developed. Porous matrix coated on the wall of the channel in the microfluidic chip to provide a surface-enlarging matrix,...
This paper presents the fabrication and preliminary test results of a MEMS cell stimulator, which has never been tried and reported. It provides a new tool of cell stimulation, culture and analysis for stem cell research. MEMS cell stimulator is designed to apply compressive pressure to the hMSCs (human mesenchymal stem cells) for inducing chondrogenesis. MEMS cell stimulator is based on the pneumatic...
Polycrystalline diamond (poly-C) was used as a piezoresistive position sensor in a cochlear implant probe for its high piezoresistive sensitivity. Based on previous studies [Spelman, FA, 1999], the 3rd generation cochlear probe with poly-C position sensors were designed and fabricated with several new improvements for compatibility and integration with the Si-based bulk micromachining technology....
We describe a prototype micro-laboratory for rapid genetic identification of bacterial pathogens from infected human body fluids. The core module of the detection platform is a microfabricated electrochemical sensor array. Picomolar amperometric detection is achieved through formation of a DNA sandwich between capture and detector probe pairs and bacterial 16S rRNA, coupled with an oxidoreductase...
A novel method for constructing an automated cell fractionation system was developed by integrating traveling-wave dielectrophoresis (twDEP) and laminar flow on a single biochip-based device. Novel electrodes designs on indium tin oxide (ITO) glass and pre-molded poly(dimethylsiloxane) (PDMS) microfluidic chamber, as well as an automated cell tracking method based on a computer-assisted image analysis...
Nanoparticles containing the infrared-to-visible up-converting phosphors (UCP) ytterbium and erbium and co-doped with sodium yttrium fluoride were synthesized with diameters ranging from 30 nm to 50 nm. These high luminescence efficient UCP beads were employed as detection labels and applied in microarrays for the detection of specific nucleic acid hybrids to identify bacteria for the first time....
This paper presents a novel MEMS-based DNA computer for solving SAT problems. A modified back-side exposure process and a low-cost fluorescent microscope system for image acquisition are used for the computing experiment such that no time-consuming alignment procedures and delicate sample applying equipment are required for the proposed microarray-based DNA computing. Moreover, experimental results...
This study presents the design, simulation, fabrication and preliminary results of a cell trap device for detecting the early stage of apoptosis, PS (phosph-atidylserine) exposure, under single-cell resolution. The structure of biochip is consisted of ITO top electrode, PDMS flow chamber, bottom electrode array and SU-8 3D microstructure array. In order to achieve single-cell resolution, we utilize...
We present the first single metal layer flexible microelectrode arrays designed for intraocular implantation that utilize parylene C as their primary structural and insulating material. These electrodes are fabricated as a key component of an intraocular retinal prosthesis comprising a radio-frequency coil for power and data transfer, a packaged high lead-count telemetry-recovery and driving application-specific...
Electrowetting-on-dielectric (EWOD) is a new method for moving liquids in micro-total-analysis system. One of the biggest challenges for all EWOD-based biofluidic chips is preventing and minimizing nonspecific adsorption of biomolecules on the hydrophobic surfaces. In this paper, we theoretically and experimentally analyze the adsorption in EWOD, which is mainly induced by hydrophobic interaction...
This paper presents a smart immunosensing biochip using a novel electrochemical method for the portable clinical diagnostics system. The fluid flow of this device can be induced by capillary attraction force only and controlled by a geometrical structure. By this fluid transport mechanism, it does not require external electrical power or control circuit parts. Therefore it is suitable for disposable...
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