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The objective of this study was to develop a standardized protocol for the capturing and analysis of endoscopy digital images for subsequent use in a computer aided diagnosis (CAD) system in gynaecological cancer. Images were captured at optimum illumination and focus at 720times576 pixels using 24 bits color in the following cases: (i) for a variety of testing targets from a color palette with known...
This study is part of the research of improving early detection of breast cancer in screening mammograms by focusing on computerized analysis and detection of cancers missed by radiologists. It is directed to the analysis of breast density in missed cancer cases and the effect of tissue density on cancer detection. A total of 100 missed cancer cases were collected which were used to generate three...
Microscopic imaging is an important phenotyping tool to characterize the phenotype (e.g., morphology and behavior) change caused by genotype manipulation such as mutation and gene knockout. Recently we use high resolution microscopic imaging to study the morphological change on mouse placenta induced by retinoblast (Rb) gene knockout. In order to assess the morphological change we first segment each...
Rapid progress in functional genomics is yielding unparalleled opportunities for cancer biomarker discovery. Several procedures including data collection, analysis, verification, and visualization are necessary to identify cancer biomarkers from continuously updated microarray data, which are derived from multiple tissue sources using various methods. BioMarker is designed to integrate these procedures...
Hereditary non-polyposis colorectal cancer (HN-PCC) is one of the most common autosomal dominant diseases in developed countries. Here, we report on a system to identify the risk of a family having HNPCC based on its history. This is important since population-wide genetic screening for HNPCC is not currently considered feasible due to its complexity and expense. If the risk of a family having HNPCC...
In the diagnosis and therapy of prostate cancer, it is critical to measure the volume of the prostate and locate its boundary. Three-dimensional transrectal ultrasound (3D TRUS) imaging has been demonstrated to be a useful technique to perform such a task. Due to image speckle as well as low contrast in ultrasound images, segmentation of the prostate in 3D US images is challenging. In this paper,...
To explore the characteristics of thermo-source of breast tumors on thermal texture maps. Compared with the histological results, thermo-source characteristics on TTM in 106 cases with breast mass, who would undergo breast surgery, were analyzed according to the parameters such as the depth, morphology, structure, and temperatures of abnormal heat foci in order to find the differences between benign...
This paper reported the identification and mechanism of dynamic mass redistribution in living cells mediated by epidermal growth factor receptor (EGFR) activation using resonant waveguide grating (RWG) biosensors. In response to epidermal growth factor (EGF) stimulation, human epidermoid carcinoma A431 cells gave rise to a dynamic response due to dynamic mass redistribution (DMR) in the cells. The...
Laser-induced fluorescence spectroscopy (LIF) and Raman spectrum of serum for detection of colon cancer and rectum cancer were investigated in this paper. The aim of this study was that using Raman spectrum and LIF analysis the serum of colon cancer and rectum cancer for found the difference compared to normal, the difference was found. For example: the peaks intensity and red shift are both different...
Automatic detection of microcalcifications in mammograms constitutes a helpful tool in breast cancer diagnosis. Radiologist's confidence level on microcalcification detection would be improved if a probability estimate of its presence could be obtained from computer-aided diagnosis. In this paper we explore detection performance of a simple Bayesian classifier based on Gaussian mixture probability...
A common complication of breast cancer treatment is the development of shoulder stiffness on the affected side. Rehabilitation interventions exist, but scientific guidelines for safe early motion are lacking. A 3-dimensional model of the shoulder and the pectoralis major muscle was used to interactively generate the total muscle excursion during the simulated motions. From these simulation results...
Automatic contouring for breast tumors using medical ultrasound (US) imaging may assist physicians, without relevant experience, in making correct diagnoses. This study utilizes the watershed transform and active contour model (ACM) to overcome the natural properties of US images, speckle, noise and tissue-related textures, to segment the breast tumors precisely. The watershed transform is performed...
Masses due to benign breast diseases and tumors due to breast cancer present significantly different shapes on mammograms. In general, malignant tumors appear with rough and complex boundaries or contours, whereas benign masses present smooth, round, or oval contours. Fractal analysis may be used to derive shape features to perform pattern classification of breast masses and tumors. Several procedures...
Here, a filter with series of pools and dams structures was designed and fabricated, utilizing size difference between tumor and blood cells. The cell mixtures were successfully filtrated out by the filter, and separation efficiency was up to 99.9%. To evaluate the filter, physical models were made to describe the behaviors of different cells in microfluidic systems. As the ability of cell deformation...
High-throughput mass spectrometry and statistical analysis methodologies are promising technologies to aid the medical diagnostics field by detecting the cancer-related proteomic markers. We propose statistical methods to cull the potential markers by ranking them in relations to their power of separability distinguishing cancerous patients from normal persons or among different cancer stages. To...
According to the results of quantitative pattern recognition for 153 N-nitroso compounds (NNCs) based on Di-region theory, it is put forward that the esters formed from the metabolism of NNCs on beta- or gamma-position could be alkylating agents of DNA bases with the anchimeric assistance of the N-nitroso group. This viewpoint, combined with the conception of alpha-metabolism activation, can explain...
The aim of this paper is to analyze and discriminate the pathological voice by separating signal into periodic and aperiodic parts. Separation was performed recursively from the residual signal of voice signal. Based on initial estimation of aperiodic part of spectrum, aperiodic part is decided from the extrapolation method. Periodic part is decided by subtracting aperiodic part from the original...
Brachytherapy is a minimally invasive interventional surgery used to treat prostate cancer. It is composed of three steps: dose pre-planning, implantation of radioactive seeds, and dose post-planning. In these procedures, it is crucial to determine the positions of needles and seeds, measure the volume of the prostate gland. Three-dimensional transrectal ultrasound (TRUS) imaging has been demonstrated...
An automated image analysis method for quantification of the size and number of lymph nodes in surgical specimens of stage II colorectal cancer is presented. The quantification is made using routine histopathologic sections of lymph nodes that have been dissected by pathologists from resection specimens. The hematoxylin and eosin stained sections on slides are imaged with a standard image scanner...
With the advancement of the imaging facility and image processing technique, computer assisted surgical planning and image guided technology have become increasingly used in neurosurgery. For MRI has the characteristic of multi-spectral image data, so knowledge-base techniques is widely used in brain MRI segmentation. Here we recognize the location of the tumor automatically and provide an accurate...
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