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The authors describe the coordinate system transformations necessary to reformat published anthropometric data for inclusion in a predefined 3-D body model. A 3-D dynamic model requires input from several sources that often have different frames of reference. Through a series of coordinate transformations and data manipulations, the various frames of reference can be brought into coincidence. This...
The authors describe a 3-D computer animation of kinematic data with superimposed center of gravity and force vectors on a wire-like figure. This animation is used to provide ease in visualizing kinematic and kinetic data obtained by the motion analysis system at the Biomotion Laboratory at Massachusetts General Hospital. The animation permits qualitative assessment of data validity. In conjunction...
A system was developed to simulate the operation of an intra-aortic balloon pump (IABP) console, and the corresponding patient response. It displays aortic pressure and left ventricular pressure as sliding waveforms in real-time, as well as all of the IABP controls. The system is designed to execute in a PC architecture. The embedded arterial model is based on a multiple-order nonlinear system model...
Summary form only given. The authors review the properties and functional characteristics of the H/sub 1/ receptor and postulate the nature of the ligand-receptor activation site using molecular modeling techniques. A model of the surface of the active site on the receptor was postulated and constructed using Sybyl software on a personal Iris workstation. The surface properties were inferred using...
Clozaril, an antipsychotic agent, has several harmful side effects. An established computerized database was used to monitor Clozaril patients in New York State (NYS) Psychiatric Centers. Six centers with a total of 138 Clozaril patients were monitored from June to December 1991. White blood cell test results (WBC, % Gran (percentage of granulocytes), Hash Gran (absolute number of granulocytes)) were...
An attempt was made to develop a small, expandable neural network that would oscillate when presented with an appropriate stimulus. The focus of the research is the modification and expansion of a single neuron simulation into a simulation of an interconnected multineuron oscillatory network. A single neuron model based on the work of Hodgkin-Huxley is used to develop a simulation of a generalized,...
A system has been developed for multineuronal studies through a single extracellular microelectrode. This system is used to detect and study the behavior of local neuronal nets, formed by the dendritic appendages of tectral cells in the superficial tectum of the frog. The system consists of a software package for visual stimulation, spike detection, and classification, calculation of cross-correlograms...
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