Ultrasonic (US) brain stimulation, has been demonstrated to noninvasively alter neuron activity in animals and humans. Capable of non-invasive transmission trough skull with fine focal size (∼mm), it is an encouraging means and a good alternative to existing stimulating strategies. However, the bio-effects of US are diverse and thus it is crucial to develop precise neuron control strategies for later translation. Here we focus on the mechanisms of gating mechanosensitive ion channels (MCs) by US and explored as fundamentals for the developing selective US neuron stimulation.