Special articles refer to microorganisms, human tissues, biological products, blood and blood products in need of special management in entry administration. Such articles are related to national biological safety and people's life safety, and have always been the key regulatory objects in entry and exit inspection and quarantine. How to improve the efficiency of the inspection and quarantine supervision system has become the common aspiration of governments, enterprises, research institutes and other social sectors while ensuring the regulatory safety. On the basis of the original inspection and quarantine supervision system for special articles, this paper further improved the supervision and management process and established a more rigorous whole-process supervision system for special articles to better serve the social and economic development and scientific and technological progress while supervising the safety of special articles.