The ability to perform real-time signal analysis on physiological signal is important in today's technology. This allows physician to monitor their patient's health condition and provide the necessary action immediately. To obtain accurate measurement of this signal, proper signal interface between the patient body and the signal analyzer is crucial. In this work, a microprocessor system interfaced with an ADC and a pulse sensor is implemented in FPGA hardware. An experiment is carried out to analyze the performance of the system by executing real-time data acquisition system on various test data. From the experiment results, the system is able to achieve good results as compared to the direct measurement using oscilloscope. Based on the power analysis results, the proposed system has total power dissipation around 200.63 mW to 201.17 mW.