In this article, we present the architectural and algorithmic details for a COgnitive System Architecture that uses a Centralized Ontology with Specific Algorithms (COSA2). COSA2 is a layered intelligent agent framework on the basis of the modified Rasmussen model of human performance. It encompasses integrated algorithmic support for goal-driven situation interpretation, dynamic planning and plan execution, as well as provisions for reactive behavior. A unique feature is the claim for an expressive, centralized ontology representation, used by all functions to ensure consistency. The framework is being applied to different problems in the domain of uninhabited aerial vehicles. The modeling and processing details described in this article are illustrated by a simplified example from the intelligent onboard systems management domain.