In view of the degree of the information is not high, the formation of the various parts as a system of “information islands” and other issues in printing and dyeing industry, this paper studied a control system for rotary screen printing machine multi-axis coordinated motion control as the core based on CAN bus, to enhance the multi-axis synergistic motion accuracy as the goal. A study from the following aspects, the inspect method of real time synchronization control, the position synchronization arithmetic of rotary screens, to improve motion control accuracy of the synchronization between network nodes, as well as, Multi-axis coordinated motion control algorithm ,and realized absolute position synchronization between the rotary screen, as compared with other similar systems with a high accuracy, high reliability and low failure rate and long service life and so on. In practical applications, and to effectively improve the accuracy of the printing and production, the whole operation smooth and reliable, has received satisfactory control effect.