This research aims at exploring the effects of applying computer-assisted music instruction to Chinese musical instruments. To achieve the purpose, this research began with developing computer-assisted instruction software for Chinese musical instruments, and tested it with 228 students in a vocational high school. This research adopted the pre and post-test nonequivalent control group design. Three classes were assigned to the experimental group with ldquoCAMI in Chinese musical instrumentsrdquo, and another three classes were assigned to the control group with ldquotraditional narrative teaching approach.rdquo The entire experiment lasted 5 weeks. Collected data were analyzed by SPSS for Windows10.0 and LISREL 8.52. The statistical approaches for this study include descriptive statistical analysis, analysis of covariance (ANCOVA), and structural equation modeling analysis (SEM). The conclusions are as follows:1. Regarding to studentspsila learning achievement in ldquolearning Chinese musical instrumentsrdquo, CAMI approach is superior to the traditional narrative teaching approach. 2. In ldquolearning Chinese musical instrumentsrdquo course, students possess an affirmative perspective in the application of CAMI approach. 3. The relationship among ldquosoftware interfacerdquo, ldquolearning attituderdquo and ldquocognition learning achievementrdquo tends to be positive. 4. CAMI in Chinese musical instruments software is a satisfactory assisting tool for teachers in ldquolearning Chinese instrumentsrdquo course.