Vessel boundary detection and 3D modeling is a difficult but necessary task in analyzing the mechanics of inflammation and the structure of the microvasculature. We present in this paper a method of analyzing this structure by the means of the deformable model (using GVF Snake) for vessel boundary detection and three-dimensional reconstruction. For this purpose, we used a virtual vessel model and produced synthetic images. From these images, we obtained contours of vessels by the GVF Snake and then reconstructed a three-dimensional structure by using the coordinates of the Snakes