Activity concentrations of 210 Po and 210 Pb in the species Mytilus galloprovincialis from Croatian Adriatic coast were determined. The samples were collected in thirteen sampling places which are also a part of Croatian Mediterranean mussel watch project. The results of 210 Po and 210 Pb activity concentrations were found to vary between (22.1±2.5)–(207±21)Bqkg −1 fresh weight and (2.8±1.4)–(9.3±0.7)Bqkg −1 fresh weight, respectively. 210 Po/ 210 Pb ratio ranged between 6.2 and 30.7. The highest measured activities were found in the enclosed basins of the Neretva channel, where the majority of Croatian mussel cultivation is taking place. The estimated consequent average total annual effective ingestion dose due to 210 Po and 210 Pb from mussel consumption in Croatian coastal region is 202±99μSv with 96% contribution of 210 Po to the total effective dose.