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The transcriptional repressor Rex is a sensor of the intracellular NADH/NAD + redox state through direct binding of NADH or NAD + . Homodimeric Rex protein from Thermus aquaticus (T-Rex) and Bacillus subtilis (B-Rex) exists in several different conformations. In both organisms, Rex in complex with NADH has the DNA binding domains packed together at the dimer interface, whereas in the...
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