Exposure to sunlight is expected to amplify the age- and site-related changes of the skin. This study examined the number and type of infiltrated cells in the dermis of normal-appearing female facial skin by emphasizing the role of aging and site. H-E-stained sections from non-inflammatory nevi located on female facial skin (134 cases) and on the female trunk (73 cases) were evaluated retrospectively. The number of lymphoid cells, histiocytes and granulocytes (neutrophils and eosinophils) at the periphery of the lesion were counted microscopically in 6 fields of each section, and designated as cells/mm 2 . In facial skin, the number of lymphoid cells increased with age up to 48 years old (average 427 cells/mm 2 ), while histiocytes did not change with age (148 cells/mm 2 ) and the number of granulocytes was minimal. In the un-exposed skin of the trunk, the number of lymphoid cells (293 cells/mm 2 ) and histiocytes (126 cells/mm 2 ) did not change with age. These results suggest that infiltrated lymphoid cells are involved in the morphological or functional aging of facial skin.