We have previously reported that elevated levels of an acute phase reactant. C-Reactive Protein (CRP), are common in pts with unstable angina (UA) and related to short term outcome. To assess whether the increase of CRP in UA is a transient condition or persists after clinical stabilization, and whether elevated levels of CRP after stabilization are still associated with prognosis, we measured CRP in 34 patients (pts) with UA: blood samples were taken at discharge from the hospital and 3 months (3M) after the index event (during a stable phase of the disease). Clinical follow-up of all pts was performed for 12 months.CRP values (normal<3mg/l) are expressed as median and range. At discharge, 13/34pts (38%) had a CRP value >3mg/l (9mg/l, range 3.629.2). and 21/34pts (62%) had a CRP value<3mg/l (2.4 mg/l, range 0.6–2.8). All 13 pts with elevated CRP at discharge, but one, had elevated levels of CRP also at 3 months, and 9 of them had a coronary event (2 pts myocardial infarction, 7 pts recurrence of instability) within one year of follow-up (mean 159±91 days). Conversely, only 1/21 pts with low CRP at discharge had a myocardial infarction at 10 months (p<0.001 vs pts with elevated levels at dischargel; of note, at 3 months also this pt had increased levels of CRPOur data suggest that in pts with UA, elevated CRP levels at discharge and at 3 months (during a quiescent phase of the disease) are associated with new coronary events (recurrence of instability and acute myocardial infarction).