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The interaction between HIV gp120 and galactose-containing cell surface glycolipids such as GalCer or Gb 3 is known to facilitate HIV binding to both CD4 + as well as CD4 − cells. In an effort to develop small molecule HIV-1 entry inhibitors with improved solubility and efficacy, we have synthesized a series of C-glycoside analogs of GalCer and tested their anti HIV-1 activity...
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