NO scavenging (r=−0.6363; p=0.0108). The anti-inflammatory capacity of phlorotannin extracts was further evaluated using RAW 264.7 macrophages stimulated with bacterial lipopolysaccharide, as model of inflammation. The extracts studied were not toxic at the tested concentrations (31.25–500μg/mL). F. vesiculosus from wild origin was the most effective in reducing NO in cell culture medium (IC25=56.52μg/mL), closely followed by other seaweed species under study. The IMTA species was the less effective one (IC25=317.41μg/mL). According to the results obtained, phlorotannin extracts from Fucales arise as potentially beneficial in inflammation-related conditions, effectively acting upon enzymatic and non-enzymatic inflammatory targets.