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The loss of skeletal muscle mass with aging has been attributed to a decline in muscle fiber number and muscle fiber size.To define to what extent differences in leg muscle cross-sectional area (CSA) between young and elderly men are attributed to differences in muscle fiber size.Quadriceps muscle CSA and type I and type II muscle fiber size were measured in healthy young (n=25; 23±1y) and older (n=26;...
Sarcopenia, defined as muscle weakness and fiber atrophy, of respiratory muscles such as the diaphragm (DIAm) has not been well characterized. The DIAm is the main inspiratory muscle and knowledge of DIAm sarcopenia is important for establishing the effects of aging on respiratory function. We hypothesized that aging is associated with a loss of DIAm force and reduced fiber cross-sectional area (CSA),...
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