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Despite great efforts, it is not known which oligomeric population of amyloid beta (Aß) peptides is the main neurotoxic mediator in Alzheimer's disease. In vitro and in vivo experiments are challenging, mainly because of the high aggregation tendency of Aß (in particular of Aß 1–42 peptide), as well as because of the dynamic and non covalent nature of the prefibrillar aggregates. As a step forward...
The subject of this study is comparison of imidazolium based dynamic and covalent coatings of the quartz capillary wall on the example of catecholamines determination. A way of synthesis of covalent coatings was proposed. For the first time different type of on-line sample preconcentration techniques (field-amplified sample stacking (FASS), head-column field amplified sample stacking (HC FASS), electrostacking,...
Capillary electrophoresis (CE) instrument was used for the generation of a robust and reliable nanoreactor for enzymatic assays in the context of antithrombotic drug screening. The activity of the screened molecules was monitored in a quick and fully automated fashion using only few nanoliters of reactants. To achieve this goal, the targeted enzyme (thrombin) and the chromogenic substrate with or...
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