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The newly synthesized benzimidazole compounds were suggested to be inhibitors of Plasmodium falciparum plasmepsin II and human cathepsin D by virtual screening of an internal library of synthetic compounds. This was confirmed by enzyme inhibition studies that gave IC 50 values in the low micromolar range (2–48μM). Ligand docking studies with plasmepsin II predicted binding of benzimidazole...
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