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The hematopoietic supporting abilities are known to be impaired in marrow stromal layers developed from patients with acute myeloid leukemia (AML). In this study, fibroblast growth factor-4 (FGF-4), epidermal growth factor (EGF) or transforming growth factor-β1 (TGF-β1) were studied to see whether these growth factors can modify the functional development of leukemic stromal layers. Adherent stromal...
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