To evaluate the effects of an 8-week multimodal physical therapy program with multimedia support on cancer-related fatigue, cortisol and IgA salivary concentrations, α-amylase activity and neck-shoulder mobility, in breast cancer.This was a prospective randomised clinical trial using between-groups design. Seventy-eight breast cancer survivors during first year after treatment participated. Participants were assigned into 2 groups: CUIDATE group (multimodal program) or control group (usual care). CUIDATE program consisted of 24h of individual physical training and 12h of stretching and massage interventions. Measurements included the Piper Fatigue Scale, cortisol and IgA salivary levels, α-amylase activity and active cervical-shoulder range of motion.Compared to the control group, CUIDATE group showed a estimated improvement for total fatigue score of −2.49 points immediately after treatment (between-group effect size 0.68; P<0.001) and −1.43 at 6 month follow-up (between group effect size: 0.43; P<0.01). CUIDATE group showed a decrease in α-amylase activity of −41.77U/ml immediately after treatment compared to the control group (between-group effect size: 0.24; P=0.046). Further, significant between-group improvements for shoulder flexion, horizontal abduction, cervical extension and lateral-flexion (between-group effect sizes ranging 0.30–0.75; all P<0.05) after treatment were also found.An 8-week multimodal physical therapy program was effective at short and 6 month follow-up for decreasing fatigue in breast cancer survivors. The program was also effective in decreasing α-amylase activity and improving shoulder and cervical range of motion.
Financed by the National Centre for Research and Development under grant No. SP/I/1/77065/10 by the strategic scientific research and experimental development program:
SYNAT - “Interdisciplinary System for Interactive Scientific and Scientific-Technical Information”.