Comorbidity of depression and opioid addiction is highly prevalent, but their outcome in MMT is not consistent.To compare between depressed and non-depressed MMT patients.Hamilton depression scale scores (taken during a psychiatric assessment) were studied among MMT patients on admission or during treatment (cutoff for depression>18).A total of 498 MMT patients were studied. Depression proportion was 22.5%, and 23.2% among 263 who were studied on admission; the depressed vs. non-depressed on admission did not differ in female proportion (19.7% vs. 25.6%), age of admission (43.2±10.4), opiate use onset (21.8±6.3) and education years (9.5±2.8), but had higher proportion of cocaine (55.7% vs. 35.1%, P=0.005), and benzodiazepine abuse (73.8% vs. 58.4%, P=0.04). Retention was high and similar (80.3 vs. 82.9% P=0.7) and of those who stayed one year, cocaine and benzodiazepine were still higher among the depressed patients (cocaine: 43.8% vs. 23.2%, P=0.03; BDZ: 61.2% vs. 40%, P=0.01). Compared to the non-depressed, among all study group (n=498) the depressed patients presented higher proportion of rape history (25% vs. 9.5%, P=0.001), of suicide attempts (43.8% vs. 25%, P=0.001) with only a trend of shorter cumulative retention in MMT of mean 9.4y (95% CI 7.8–10.7) vs. 11.5 (95% CI 10.5–12.5, P=0.07).Despite cocaine and benzodiazepine abuse on admission, depressed succeeded similarly to the non-depressed in the first year retention in treatment. Intervention is recommended since admission, as their long-term retention seems to be shorter, later on, and their ability to discontinue cocaine and benzodiazepine abuse is clearly hampered.