A subset S of vertices in a graph G=(V,E) is a connected dominating set of G if every vertex of V∖S is adjacent to a vertex in S and the subgraph induced by S is connected. The minimum cardinality of a connected dominating set of G is the connected domination number γc(G). The girth g(G) is the length of a shortest cycle in G. We show that if G is a connected graph that contains at least one cycle, then γc(G)≥g(G)−2, and we characterize the graphs obtaining equality in this bound. We also establish various upper bounds on the connected domination number of a graph, as well as Nordhaus–Gaddum type results.