Objective: Although few studies have examined cardiovascular disease in Asian-American subgroups separately, limited data in Asian Americans strongly suggest that some subgroups are at increased risk. The present study examined modifiable cardiovascular risk factor profiles as a function of Asian ethnicity. Methods: This descriptive cross-sectional pilot study recruited Asian-American women (N=147) in northeast Florida including Cambodians (n=39), Chinese (n=36), Filipinos (n=49), and Vietnamese (n=23). Risk factors included blood pressure, body mass index, waist circumference and blood lipids. Results: Filipino participants (41%) had >=4 risk factors compared to 21% Cambodian, 13% Vietnamese and 0% Chinese. The Chinese had significantly more participants (44%) with the absence of CVD risk factors compared to all other subgroups. Obesity rate (18%), mean BMI: 26+/-5kg/m 2 and mean triglycerides (173+/-103mg/dL) were highest in Filipinas (n=49). The Chinese (n=36) had a low rate (4%) of obesity with a mean BMI of 23+/-3kg/m 2 and the least risk factors along with the lowest triglycerides (88+/-44mg/dL). Cambodians (n=39; BMI of 24+/-3kg/m 2 ) and Vietnamese (n=23; BMI: 22+/-3kg/m 2 ) had low rates of obesity with comparable rates of unhealthy lipids and hypertension as the Filipinas. Conclusions: Modifiable CVD risk factor profiles significantly differed as a function of ethnicity supporting the premise that Asian-American women cannot be categorized as one group and the traditional ''one size fits all'' prevention or treatment of CVD risk factors should be re-considered.