Objective: Preeclampsia is preceded by early-pregnancy maladaptation in volume homeostasis and renal function. We tested the hypothesis that abnormalities in these systems persist postpartum, not only during the menstrual cycle (MC)(J Soc Gynecol Invest 97:[abs]70), but also in the first weeks of a subsequent pregnancy. Methods: We measured the following variables midfollicular (FP) and midluteal (LP) during the MC, and at 5 (AM5) and 7 wks amenorrhea (AM7), in 20 normotensive ex-PE and 7 controls: Glomerular filtration rate (GFR, inulin clearance, ml.min - 1 .1.73 m 2 ), active plasma renin concentration (APRC, nmol.L - 1 ), atrial natriuretic peptide (ANP, μmol.L - 1 ), plasma volume (PV, dextran-70 dilution, L) and venous compliance (VC, plethysmograph, ml.dl - 1 .mmHg - 1 ). The patterns of change between nonpregnant and pregnant state were tested by Friedman (p < 0.05 = * ). Differences between groups at each measurement session were analyzed by Mann-Whitney-U test (p < 0.05 = arrows). Results: Medians and ranges of all measurements are listed in the table.Conclusion: Although PV, GFR and APRC increase in both groups between nonpregnant and pregnant phases, ex-PE differed from controls by a concomitant rise in ANP paralleled by a lack of increase in VC. We speculate that ex-PE have a reduced capacity to increase venous compliance in response to pregnancy when compared to controls.