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Aqueous dissolution of a synthetic chloride-containing Mg 2+ –Al 3+ layered double hydroxide was studied at 298K as a function of pH. Mild acidification (final pH 9 –5) results in incongruent dissolution of Mg 2+ , exclusively. Formation of an amorphous Al(OH) 3 passive layer prevents further Mg 2+ leaching, thus dissolved Mg 2+ amounts for only 20%...
A new approach to improve gastric solubility and control intestinal release of drugs, based on the formation of new nanostructured compounds, is described. The nanostructured system is an inorganic–organic hybrid material constituted by an inorganic material, belonging to the hydrotalcite-like compound (HTlc), and by flurbiprofen (FLUR), a nonsteroidal antiinflammatory drug belonging to class II of...
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