We report the use of thin-film organic photodiodes as integrated optical detectors for microscale chemiluminescence. The copper phthalocyanine–fullerene (CuPc–C 60 ) small molecule photodiodes have an external quantum efficiency of ∼30% at 600–700nm, an active area of 2mm×8mm and a total thickness of ∼2mm. Simple detector fabrication, based on layer-by-layer vacuum deposition, allows facile integration with planar chip-based systems. To demonstrate the efficacy of the approach, CuPc–C 60 photodiodes were used to monitor a peroxyoxalate based chemiluminescence reaction (PO-CL) within a poly(dimethylsiloxane) (PDMS) microfluidic device. Optimum results were obtained for applied reagent flow rates of 25μL/min, yielding a CL signal of 8.8nA within 11min. Reproducibility was excellent with typical relative standard deviations (R.S.D.) below 1.5%. Preliminary quantitation of hydrogen peroxide yielded a detection limit of ∼1mM and linearity over at least three decades. With improved sensitivity and when combined with enzymatic assays the described integrated devices could find many applications in point-of-care diagnostics.